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The case of GWAS of obesity: does body weight control play by the rules?

Müller, Manfred J. ; Geisler, Corinna ; Blundell, John ; Dulloo, Abdul G. ; Schutz, Yves ; Krawczak, Michael ; Bosy-Westphal, Anja ; Enderle, Janna ; Heymsfield, Steven B.

In: International Journal of Obesity, 2018, vol. 42, no. 8, p. 1395–1405

As yet, genome-wide association studies (GWAS) have not added much to our understanding of the mechanisms of body weight control and of the etiology of obesity. This shortcoming is widely attributed to the complexity of the issues. The appeal of this explanation notwithstanding, we surmise that (i) an oversimplification of the phenotype (namely by the use of crude anthropometric traits) and...