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In vivo gene delivery of urokinase-type plasminogen activator with regulatable lentivirus induces behavioural changes in chronic cocaine administration

Bahi, Amine ; Boyer, Frederic ; Gumy, Christèle ; Kafri, Tal ; Dreyer, Jean-Luc

In: European Journal of Neuroscience, 2004, vol. 20(12), p. 3473

Serine proteases play a key function in extracellular processes affecting central nervous system plasticity. Recently, the role of extracellular proteolytic processes in regulating synaptic structure and function has been described. However, to date direct evidence linking extracellular serine protease activity with drug-related behavioural changes has not been documented. Importantly, in a...