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    Université de Fribourg

    Are integrins still practicable targets for anti-cancer therapy?

    Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

    In: Cancers, 2019, vol. 11, no. 7, p. 978

    Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

    Université de Fribourg

    MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

    Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, OrcID, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

    In: Cells, 2019, vol. 8, no. 5, p. 388

    Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...