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Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression

Barras, David ; Lorusso, Girieca ; Lhermitte, Benoît ; Viertl, David ; Rüegg, Curzio ; Widmann, Christian

In: International Journal of Cancer, 2014, p. -

The p120 RasGAP protein negatively regulates Ras via its GAP domain. RasGAP carries several other domains that modulate several signaling molecules such as Rho. RasGAP is also a caspase-3 substrate. One of the caspase-3-generated RasGAP fragments, corresponding to amino acids 158–455 and called fragment N2, was previously reported to specifically sensitize cancer cells to death induced by...