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Assessment of Driving Capability Through the Use of Clinical and Psychomotor Tests in Relation to Blood Cannabinoids Levels Following Oral Administration of 20 mg Dronabinol or of a Cannabis Decoction Made with 20 or 60 mg Δ9-THC

Ménétrey, Annick ; Augsburger, Marc ; Favrat, Bernard ; Pin, Marie A. ; Rothuizen, Laura E. ; Appenzeller, Monique ; Buclin, Thierry ; Mangin, Patrice ; Giroud, Christian

In: Journal of Analytical Toxicology, 2005, vol. 29, no. 5, p. 327-338

THCCOOH concentrations in whole blood: Are they useful in discriminating occasional from heavy smokers?

Fabritius, Marie ; Favrat, Bernard ; Chtioui, Haithem ; Battistella, Giovanni ; Annoni, Jean-Marie ; Appenzeller, Monique ; Dao, Kim ; Fornari, Eleonora ; Lauer, Estelle ; Mall, Jean-Frédéric ; Maeder, Philippe ; Mangin, Patrice ; Staub, Christian ; Giroud, Christian

In: Drug Testing and Analysis, 2013, vol. 6, no. 1-2, p. 155–163

Some forensic and clinical circumstances require knowledge of the frequency of drug use. Care of the patient, administrative, and legal consequences will be different if the subject is a regular or an occasional cannabis smoker. To this end, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) has been proposed as a criterion to help to distinguish between these two groups of users. However, to...

Weed or wheel! FMRI, behavioural, and toxicological investigations of how cannabis smoking affects skills necessary for driving

Battistella, Giovanni ; Fornari, Eleonora ; Thomas, Aurélien ; Mall, Jean-Frédéric ; Chtioui, Haithem ; Appenzeller, Monique ; Annoni, Jean-Marie ; Favrat, Bernard ; Maeder, Philippe ; Giroud, Christian

In: PLoS ONE, 2013, vol. 8, no. 1, p. e52545

Marijuana is the most widely used illicit drug, however its effects on cognitive functions underling safe driving remain mostly unexplored. Our goal was to evaluate the impact of cannabis on the driving ability of occasional smokers, by investigating changes in the brain network involved in a tracking task. The subject characteristics, the percentage of Δ9-Tetrahydrocannabinol in the joint, and...