Université de Fribourg

Engineering an in vitro air-blood barrier by 3D bioprinting

Horváth, Lenke ; Umehara, Yuki ; Jud, Corinne ; Blank, Fabian ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Scientific Reports, 2015, vol. 5, p. -

Intensive efforts in recent years to develop and commercialize in vitro alternatives in the field of risk assessment have yielded new promising two- and three dimensional (3D) cell culture models. Nevertheless, a realistic 3D in vitro alveolar model is not available yet. Here we report on the biofabrication of the human air-blood tissue barrier analogue composed of an endothelial cell, basement...

Université de Fribourg

Evaluation of the toxicity of graphene derivatives on cells of the lung luminal surface

Horváth, Lenke ; Magrez, Arnaud ; Burghard, Marko ; Kern, Klaus ; Forró, László ; Schwaller, Beat

In: Carbon, 2013, vol. 64, p. 45–60

Graphene-based nanomaterials are expected to have a profound impact on a broad range of applications. However, studies devoted to investigating the putative adverse health effects of these nanomaterials are hugely underrepresented in the current scientific literature. We have investigated the in vitro short-term cellular toxicity associated with graphene derivatives (GD): graphene oxide and...

Université de Fribourg

In vitro investigation of the cellular toxicity of boron nitride nanotubes

Horváth, Lenke ; Magrez, Arnaud ; Golberg, Dmitri ; Zhi, Chunyi ; Bando, Yoshio ; Smajda, Rita ; Horváth, Endre ; Forró, Lászlo ; Schwaller, Beat

In: ACS Nano, 2011, vol. 5, no. 5, p. 3800–3810

Nanotubes present one of the most promising opportunities in nanotechnology with a plethora of applications in nanoelectronics, mechanical engineering, as well as in biomedical technology. Due to their structure and some physical properties, boron nitride (BN) nanotubes (BNNTs) possess several advantages over carbon nanotubes (CNTs), and they are now commercially produced and used on a large...