Résultats de la recherche

Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

Liu, Chang ; Rajapakse, Angana G. ; Riedo, Erwin ; Fellay, Benoit ; Bernhard, Marie-Claire ; Montani, Jean-Pierre ; Yang, Zhihong ; Ming, Xiu-Fen

In: Scientific Reports, 2016, vol. 6, p. 20405

Nonalcoholic fatty liver disease (NAFLD) associates with obesity and type 2 diabetes. Hypoactive AMP-activated protein kinase (AMPK), hyperactive mammalian target of rapamycin (mTOR) signaling, and macrophage-mediated inflammation are mechanistically linked to NAFLD. Studies investigating roles of arginase particularly the extrahepatic isoform arginase-II (Arg-II) in...

OPEN IN
SONAR

Prognostic value of troponin I for infarct size to improve preclinical myocardial infarction small animal models

Frobert, Aurélien ; Valentin, Jérémy ; Magnin, Jean-Luc ; Riedo, Erwin ; Cook, Stéphane ; Giraud, Marie-Noëlle

In: Frontiers in Physiology - Clinical and Translational Physiology, 2015, vol. 6, p. 353

Coronary artery ligations to induce myocardial infarction (MI) in mice and rats are widely used in preclinical investigation. However, myocardial ischemic damage and subsequent infarct size are highly variable. The lack of standardization of the model impairs the probability of effective translation to the clinic. Cardiac Troponin I (cTnI) is a major clinically relevant biomarker.Aim: In the...

Affiner les résultats

Type de document

Institution

Collection spécifique

Langue

Auteur