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Université de Neuchâtel

The TOC complex: Preprotein gateway to the chloroplast

Andrès, Charles ; Agne, Birgit ; Kessler, Felix

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010, vol. 1803, no. 6, p. 715-723

Photosynthetic eukaryotes strongly depend on chloroplast metabolic pathways. Most if not all involve nuclear encoded proteins. These are synthesized as cytosolic preproteins with N-terminal, cleavable targeting sequences (transit peptide). Preproteins are imported by a major pathway composed of two proteins complexes: TOC and TIC (Translocon of the Outer and Inner membranes of the...