Université de Fribourg

Assessment of the effect of continuous theta burst stimulation of the motor cortex on manual dexterity in non-human primates in a direct comparison with invasive intracortical pharmacological inactivation

Roux, Camille ; Kaeser, Mélanie ; Savidan, Julie ; Fregosi, Michela ; Rouiller, Eric M. ; Schmidlin, Eric

In: European Journal of Neuroscience, 2019, p. -

Non-invasive reversible perturbation techniques of brain output such as continuous theta burst stimulation (cTBS), commonly used to modulate cortical excitability in humans, allow investigation of possible roles in functional recovery played by distinct intact cortical areas following stroke. To evaluate the potential of cTBS, the behavioural effects of this non-invasive transient...

Université de Fribourg

Fine manual dexterity assessment after autologous neural cell ecosystem (ANCE) transplantation in a non-human primate model of parkinson’s disease

Borgognon, Simon ; Cottet, Jérôme ; Moret, Véronique ; Chatagny, Pauline ; Carrara, Laura ; Fregosi, Michela ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M. ; Badoud, Simon

In: Neurorehabilitation and Neural Repair, 2019, vol. 33, no. 7, p. 553–567

Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The...

Université de Fribourg

Corticotectal projections from the premotor or primary motor cortex after cortical lesion or parkinsonian symptoms in adult macaque monkeys: a pilot tracing study

Fregosi, Michela ; Contestabile, Alessandro ; Badoud, Simon ; Borgognon, Simon ; Cottet, Jérôme ; Brunet, Jean-François ; Bloch, Jocelyne ; Schwab, Martin E. ; Rouiller, Eric M.

In: Frontiers in Neuroanatomy, 2019, vol. 13, p. -

The corticotectal projections, together with the corticobulbar (corticoreticular) projections, work in parallel with the corticospinal tract (CST) to influence motoneurons in the spinal cord both directly and indirectly via the brainstem descending pathways. The tectospinal tract (TST) originates in the deep layers of the superior colliculus. In the present study, we analyzed the...

Université de Fribourg

Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study

Fregosi, Michela ; Rouiller, Eric M.

In: European Journal of Neuroscience, 2017, vol. 46, no. 8, p. 2406–2415

Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys

Université de Fribourg

Corticobulbar projections from distinct motor cortical areas to the reticular formation in macaque monkeys

Fregosi, Michela ; Contestabile, Alessandro ; Hamadjida, Adjia ; Rouiller, Eric M.

In: European Journal of Neuroscience, 2017, vol. 45, no. 11, p. 1379–1395

Corticospinal and corticobulbar descending pathways act in parallel with brainstem systems, such as the reticulospinal tract, to ensure the control of voluntary movements via direct or indirect influences onto spinal motoneurons. The aim of this study was to investigate the corticobulbar projections from distinct motor cortical areas onto different nuclei of the reticular formation. Seven adult...

Université de Fribourg

Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys

Badoud, Simon ; Borgognon, Simon ; Cottet, Jérôme ; Chatagny, Pauline ; Moret, Véronique ; Fregosi, Michela ; Kaeser, Mélanie ; Fortis, Ekaterina ; Schmidlin, Eric ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M.

In: Brain Structure and Function, 2017, vol. 222, no. 3, p. 1193–1206

In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the “modified-Brinkman...

Université de Fribourg

Distinction between hand dominance and hand preference in primates: a behavioral investigation of manual dexterity in nonhuman primates (macaques) and human subjects

Chatagny, Pauline ; Badoud, Simon ; Kaeser, Mélanie ; Gindrat, Anne-Dominique ; Savidan, Julie ; Fregosi, Michela ; Moret, Véronique ; Roulin, Christine ; Schmidlin, Eric ; Rouiller, Eric M.

In: Brain and Behavior, 2013, vol. 3, no. 5, p. 575–595

The present study aimed to determine and confront hand preference (hand chosen in priority to perform a manual dexterity task) and hand dominance (hand with best motor performance) in eight macaques (Macaca fascicularis) and in 20 human subjects (10 left-handers and 10 right-handers).Methods: Four manual dexterity tests have been executed by the monkeys, over several weeks during learning and...