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Detection of Protein Structure of Frozen Ancient Human Remains Recovered from a Glacier in Canada Using Synchrotron Fourier Transform Infrared Microspectroscopy

Quaroni, Luca ; Christensen, Colleen R. ; Chen, Becky ; Vogl, Wayne ; Monsalve, Maria Victoria

In: Microscopy and Microanalysis, 2013, vol. 19, no. 3, p. 565-575

Three-dimensional mid-infrared tomographic imaging of endogenous and exogenous molecules in a single intact cell with subcellular resolution

Quaroni, Luca ; Obst, Martin ; Nowak, Marcus ; Zobi, Fabio

In: Angewandte Chemie International Edition, 2014, p. -

Microscopy in the mid-infrared spectral range provides detailed chemical information on a sample at moderate spatial resolution and is being used increasingly in the characterization of biological entities as challenging as single cells. However, a conventional cellular 2D imaging measurement is limited in its ability to associate specific compositional information to subcellular structures...

Synthesis, characterization and cellular location of cytotoxic constitutional organometallic isomers of rhenium delivered on a cyanocobalmin scaffold

Santoro, Giuseppe ; Zlateva, Theodora ; Ruggi, Albert ; Quaroni, Luca ; Zobi, Fabio

In: Dalton Transactions, 2015, vol. 44, no. 15, p. 6999–7008

Constitutional isomers of cyanocobalamin adducts based on a fluorescent rhenium tris-carbonyl diimine complex were prepared, characterized and tested against PC-3 cancer cells. The adducts differ only in the relative binding position of the organometallic species which is either bound at the cyano or the 5′-hydroxo group of vitamin B₁₂. When tested for their cytotoxic potency, the species...