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Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion

Knuchel, Sarah ; Anderle, Pascale ; Werfelli, Patricia ; Diamantis, Eva ; Rüegg, Curzio

In: Oncotarget, 2015, vol. 6, no. 16, p. 14300–14317

Carcinoma-associated fibroblasts were reported to promote colorectal cancer (CRC) invasion by secreting motility factors and extracellular matrix processing enzymes. Less is known whether fibroblasts may induce CRC cancer cell motility by contact- dependent mechanisms. To address this question we characterized the interaction between fibroblasts and SW620 and HT29 colorectal cancer cells in 2D...