In: Development, 2010, vol. 137, p. 2187-2196
In the developing chicken embryo yolk sac vasculature, the expression of arterial identity genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must provide a unique signal that is relevant for supporting arterial identity gene expression and is absent in veins. We analyzed factors related to flow, pressure and oxygenation in the chicken embryo vitelline...
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In: Angiogenesis, 2013, vol. 16, no. 4, p. 921-937
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In: Angiogenesis, 2013, p. 1-17
Notch is an intercellular signaling pathway related mainly to sprouting neo- angiogenesis. The objective of our study was to evaluate the angiogenic mechanisms involved in the vascular augmentation (sprouting/intussusception) after Notch inhibition within perfused vascular beds using the chick area vasculosa and MxCreNotch1(lox/lox) mice. In vivo monitoring combined with morphological ...
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In: Angiogenesis, 2013, vol. 16, no. 1, p. 123-136
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In: PLOS ONE, 2016, vol. 11, no. 3, p. e0149281
Background: Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. Objective: To establish an...
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In: American Journal of Pathology, 2009, vol. 173, p. 1173-1185
Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after treatment cessation. To assess the responses to irradiation and vascular endothelial growth factor-receptor tyrosine kinase inhibition (by the vascular endothelial growth factor tyrosine kinase inhibitor PTK787/ZK222854), mammary carcinoma allografts were investigated by vascular...
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In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, vol. 31, p. 2836-2844
Objective—The concept of vascular pruning, the “cuting-off” of vessels, is gaining importance due to expansion of angio-modulating therapies. The proangiogenic effects of vascular endothelial growth factor (VEGF) are broadly described, but the mechanisms of structural alterations by its downregulation are not known.Methods and Results—VEGF165-releasing hydrogels were applied onto the...
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In: Angiogenesis, 2009, vol. 12, no. 2, p. 113-123
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In: Angiogenesis, 2009, vol. 12, no. 2, p. 113-123
New blood vessels arise initially as blood islands in the process known as vasculogenesis or as new capillary segments produced through angiogenesis. Angiogenesis itself encompasses two broad processes, namely sprouting (SA) and intussusceptive (IA) angiogenesis. Primordial capillary plexuses expand through both SA and IA, but subsequent growth and remodeling are achieved through IA. The...
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In: Cell and Tissue Research, 2006, vol. 323, no. 3, p. 395-404
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