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Université de Fribourg

Ancient mitogenomics clarifies radiation of extinct Mascarene giant tortoises ( Cylindraspis spp.)

Kehlmaier, Christian ; Graciá, Eva ; Campbell, Patrick D. ; Hofmeyr, Margaretha D. ; Schweiger, Silke ; Martínez-Silvestre, Albert ; Joyce, Walter ; Fritz, Uwe

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–7

The five extinct giant tortoises of the genus Cylindraspis belong to the most iconic species of the enigmatic fauna of the Mascarene Islands that went largely extinct after the discovery of the islands. To resolve the phylogeny and biogeography of Cylindraspis, we analysed a data set of 45 mitogenomes that includes all lineages of extant tortoises and eight near-complete sequences of all...

Université de Fribourg

Large hydropower and water-storage potential in future glacier-free basins

Farinotti, Daniel ; Round, Vanessa ; Huss, Matthias ; Compagno, Loris ; Zekollari, Harry

In: Nature, 2019, vol. 575, no. 7782, p. 341–344

Climate change is causing widespread glacier retreat1, and much attention is devoted to negative impacts such as diminishing water resources2, shifts in runoff seasonality3, and increases in cryosphere-related hazards4. Here we focus on a different aspect, and explore the water-storage and hydropower potential of areas that are expected to become ice-free during the course of this century....

Université de Fribourg

Future shifts in extreme flow regimes in Alpine regions

Brunner, Manuela I. ; Farinotti, Daniel ; Zekollari, Harry ; Huss, Matthias ; Zappa, Massimiliano

In: Hydrology and Earth System Sciences, 2019, vol. 23, no. 11, p. 4471–4489

Extreme low and high flows can have negative economic, social, and ecological effects and are expected to become more severe in many regions due to climate change. Besides low and high flows, the whole flow regime, i.e., annual hydrograph comprised of monthly mean flows, is subject to changes. Knowledge on future changes in flow regimes is important since regimes contain information on both ...

Université de Fribourg

Myosin 1b regulates nuclear AKT activation by preventing localization of PTEN in the nucleus

Yu, Yi ; Xiong, Yuyan ; Ladeiras, Diogo ; Yang, Zhihong ; Ming, Xiu-Fen

In: iScience, 2019, vol. 19, p. 39–53

Insulin-induced AKT activation is dependent on phosphoinositide 3-kinase and opposed by tumor suppressor phosphatase and tensin homolog (PTEN). Our previous study demonstrates that myosin 1b (MYO1B) mediates arginase-II-induced activation of mechanistic target of rapamycin complex 1 that is regulated by AKT. However, the role of MYO1B in AKT activation is unknown. Here we show that silencing...

Université de Fribourg

The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach

Bouazzi, Leila ; Sproll, Patrick ; Eid, Wassim ; Biason-Lauber, Anna

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–18

The chromobox homolog 2 (CBX2) was found to be important for human testis development, but its role in the human ovary remains elusive. We conducted a genome-wide analysis based on DNA adenine methyltransferase identification (DamID) and RNA sequencing strategies to investigate CBX2 in the human granulosa cells. Functional analysis revealed that CBX2 was upstream of genes contributing to ...

Université de Fribourg

CBX2-dependent transcriptional landscape: implications for human sex development and its defects

Sproll, Patrick ; Eid, Wassim ; Biason-Lauber, Anna

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–14

Sex development, a complex and indispensable process in all vertebrates, has still not been completely elucidated, although new genes involved in sex development are constantly being discovered and characterized. Chromobox Homolog 2 (CBX2) is one of these new additions and has been identified through a 46,XY girl with double heterozygous variants on CBX2.1, causing Differences of Sex...

Université de Fribourg

Cardiovascular responses to a glucose drink in young male individuals with overweight/obesity and mild alterations in glucose metabolism, but without impaired glucose tolerance

Monnard, Cathriona R. ; Grasser, Erik Konrad

In: European Journal of Nutrition, 2019, p. -

Little is known about whether mild aberrations in glucose metabolism, which are seen in overweight/obese subjects (OW/OB) without impaired glucose tolerance, affect regulator control elements for blood pressure homeostasis. Methods Hence, we measured in age-matched male subjects with normal weight (n = 16; BMI = 22.4 kg m−2) and OW/OB (n = 11; BMI = 28.6 kg m−2) continuous...

Université de Fribourg

Telechelics based on catalytic alternating ring-opening metathesis polymerization

Pal, Subhajit ; Alizadeh, Mahshid ; Kilbinger, Andreas F. M.

In: ACS Macro Letters, 2019, vol. 8, no. 10, p. 1396–1401

We describe a protocol to synthesize alternating telechelic ROMP copolymers of 7- oxa-norbornene derivatives and cycloalkenes under catalytic conditions. These copolymers were synthesized using Grubbs’ second-generation catalyst. The sterically less hindered backbone double bonds of the resulting alternating copolymers facilitate the chain transfer (secondary metathesis) reactions. In the ...

Université de Fribourg

Functional end groups in living ring-opening metathesis polymerization

Kilbinger, Andreas

In: Synlett, 2019, vol. 30, no. 18, p. 2051–2057

Over the last two decades many synthetic methods have been reported to selectively introduce a number of different functional groups at the chain end of a living ring- opening metathesis polymer. In this personal account, I would like to focus on a few such methods developed in my research group over the last several years and how these led to the discovery of catalytic living ring-opening...

Université de Fribourg

Sequential multiple-target sensor: In3+, Fe2+, and Fe3+ discrimination by an anthracene-based probe

Finelli, Alba ; Chabert, Valentin ; Hérault, Nelly ; Crochet, Aurélien ; Kim, Cheal ; Fromm, Katharina M.

In: Inorganic Chemistry, 2019, vol. 58, no. 20, p. 13796–13806

Indium is a nonphysiological toxic metal widely used in industry. While misunderstood, its toxicity is proposed to be linked to a perturbation of Fe3+ homeostasis through the binding of In3+ ions to essential iron metalloproteins such as transferrins. Therefore, the monitoring of In3+ and Fe3+ in biological environments is of prime interest for both basic research and diagnosis. Here we...