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Université de Fribourg

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Kiss, Tamas ; Giles, Cory B. ; Tarantini, Stefano ; Yabluchanskiy, Andriy ; Balasubramanian, Priya ; Gautam, Tripti ; Csipo, Tamas ; Nyúl-Tóth, Ádám ; Lipecz, Agnes ; Szabo, Csaba ; Farkas, Eszter ; Wren, Jonathan D. ; Csiszar, Anna ; Ungvari, Zoltan

In: Published version; http://dx.doi.org/10.1007/s11357-019-00095-x, 2019, p. -

Understanding molecular mechanisms involved in vascular aging is essential to develop novel interventional strategies for treatment and prevention of age-related vascular pathologies. Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion. Importantly, in aged mice, restoration of cellular NAD+ levels by treatment with the NAD+ booster nicotinamide...

Université de Fribourg

Nine hole peg test and transcranial magnetic stimulation: useful to evaluate dexterity of the hand and disease progression in amyotrophic lateral sclerosis

Czell, David ; Neuwirth, Christoph ; Weber, Markus ; Sartoretti-Schefer, Sabine ; Gutzeit, Andreas ; Reischauer, Carolin

In: Neurology Research International, 2019, vol. 2019, p. 1–5

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with involvement of the upper and lower motor neurons. Since the loss of fine motor skills is one of the earliest signs of ALS, the hypothesis was tested if the nine hole PEG test (NHPT) and transcranial magnet stimulation (TMS) with resting-motor threshold (RMT) could be useful in monitoring disease progression. Methods. We...

Université de Fribourg

Interpretation of clinical data and hypothesis testing with the aid of self-collected data from physiology laboratory courses: a teaching approach for medical students

Grasser, Erik Konrad ; Montani, Jean-Pierre

In: Advances in Physiology Education, 2019, vol. 43, no. 4, p. 557–560

More than 50 million scientific articles were published between 1665 and 2009 (4), with millions more expected every year (6). This incomprehensible number accounts for scientific articles alone and does not encompass various “pseudo-scientific” information and articles that are spread, without any peer review process, by social media and blogs, thereby generating a potential source of...

Université de Fribourg

Olfactory dysfunction in the pathophysiological continuum of dementia

Bathini, Praveen ; Brai, Emanuele ; Alberi Auber, Lavinia

In: Ageing Research Reviews, 2019, vol. 55, p. 100956

Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing evidence show that sensory dysfunctions are one of the early signs diagnosing the conversion from physiological to pathological brain state. Smell loss represents the best characterized sense in clinical practice and is considered as one of the first preclinical signs of Alzheimer’s and Parkinson’s...

Université de Fribourg

A new alligatoroid from the Eocene of Vietnam highlights an extinct Asian clade independent from extant Alligator sinensis

Massonne, Tobias ; Vasilyan, Davit ; Rabi, Márton ; Böhme, Madelaine

In: PeerJ, 2019, vol. 7, p. e7562

During systematic paleontological surveys in the Na Duong Basin in North Vietnam between 2009 and 2012, well-preserved fossilized cranial and postcranial remains belonging to at least 29 individuals of a middle to late Eocene (late Bartonian to Priabonian age (39–35 Ma)) alligatoroid were collected. Comparative anatomical study of the material warrants the diagnosis of a new taxon,...

Université de Fribourg

Archaeometrical study of Khmer stoneware from the Angkorian period: Results from the Cerangkor Project

Thirion‐Merle, V. ; Thierrin‐Michael, Gisela ; Desbat, A.

In: Archaeometry, 2019, vol. 61, no. 6, p. 1246–1263

In the area around Angkor, Cambodia, several ceramics kilns dating from the ninth to 15th centuries ce have been discovered since 1995. The technical, typological and compositional characterization of their production has been one of the main goals of the Cerangkor Project. Samples of green‐glazed ‘Kulen‐type' stoneware and non‐ glazed stoneware produced in five kiln sites in the...

Université de Fribourg

Recent glacier and lake changes in High Mountain Asia and their relation to precipitation changes

Treichler, Désirée ; Kääb, Andreas ; Salzmann, Nadine ; Xu, Chong-Yu

In: The Cryosphere, 2019, vol. 13, no. 11, p. 2977–3005

We present an updated, spatially resolved estimate of 2003–2008 glacier surface elevation changes for the entire region of High Mountain Asia (HMA) from ICESat laser altimetry data. The results reveal a diverse pattern that is caused by spatially greatly varying glacier sensitivity, in particular to precipitation availability and changes. We introduce a spatially resolved zonation where...

Université de Fribourg

Epibenthos dynamics and environmental fluctuations in two contrasting polar carbonate factories (Mosselbukta and Bjørnøy-banken, svalbard)

Wisshak, Max ; Neumann, Hermann ; Rüggeberg, Andres ; Büscher, Janina V. ; Linke, Peter ; Raddatz, Jacek

In: Frontiers in Marine Science, 2019, vol. 6, p. -

The Arctic Svalbard Archipelago hosts the world’s northernmost cold-water ‘carbonate factories’ thriving here despite of presumably unfavourable environmental conditions and extreme seasonality. Two contrasting sites of intense biogenic carbonate production, the rhodolith beds in Mosselbukta in the north of the archipelago and the barnacle-mollusc dominated carbonate sediments...

Université de Fribourg

Isolation of 12 polymorphic tetranucleotide microsatellite markers of the leaf beetle Ophraella communa, a promising Ambrosia biocontrol agent also in Europe

Bordeyne, François ; Müller-Schärer, Heinz ; Bouchemousse, Sarah

In: Biocontrol Science and Technology, 2019, p. 1–8

Following its first record in Europe in 2013, the North American ragweed leaf beetle Ophraella communa, used already as a most successful biocontrol agent against common ragweed in China, is spreading rapidly, asking for a detailed analysis of the potential benefit and risk of this introduction for Europe. Here, we report twelve specific and polymorphic tetranucleotide microsatellite markers,...

Université de Fribourg

Tectonics of the Neuchâtel Jura Mountains: insights from mapping and forward modelling

Rime, Valentin ; Sommaruga, Anna ; Schori, Marc ; Mosar, Jon

In: Swiss Journal of Geosciences, 2019, vol. 112, no. 2, p. 563–578

This study focuses on a geological section in the Jura Mountains across the villages of Travers, La Brévine in Switzerland, and Morteau in France. Field mapping was conducted to complement and densify existing data. A kinematically and geometrically consistent forward model has been developed to understand and interpret the observed surface structures. The proposed solution features a...