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Université de Fribourg

Does the single-item self-rated health measure the same thing across different wordings? Construct validity study

Cullati, Stéphane ; Bochatay, Naike ; Rossier, Clémentine ; Guessous, Idris ; Burton‑Jeangros, Claudine ; Courvoisier, Delphine S.

In: Quality of Life Research, 2020, p. -

The self-rated health (SRH) item is frequently used in health surveys but variations of its form (wording, response options) may hinder comparisons between versions over time or across surveys. The objectives were to determine (a) whether three SRH forms are equivalent, (b) the form with the best construct validity and (c) the best coding scheme to maximize equivalence across forms.

Université de Fribourg

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Volery, Maryse ; Scherz, Valentin ; Jakob, William ; Bandeira, Diane ; Deggim-Messmer, Vanessa ; Lauber-Biason, Anna ; Wildhaber, Johannes ; Falquet, Laurent ; Curtis, Nigel ; Zimmermann, Petra

In: BMJ Open, 2020, vol. 10, no. 6, p. e036275

Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether...

Université de Fribourg

Toward specific ways to combine ketamine and psychotherapy in treating depression

Hasler, Gregor

In: CNS Spectrums, 2020, vol. 25, no. 3, p. 445–447

In major depression, remission rate in response to monoaminergic antidepressant is around 50%. The lack of strong synergies between classical antidepressants and psychotherapy may be due to the molecular effects of classical antidepressants. They modulate synapses but they do not substantially influence synaptogenesis. They also increase brain-derived neurotrophic factor (BDNF). However, for...

Université de Fribourg

Increased anxiety after stimulation of the right inferior parietal lobe and the left orbitofrontal cortex

Grieder, Matthias ; Homan, Philipp ; Federspiel, Andrea ; Kiefer, Claus ; Hasler, Gregor

In: Frontiers in Psychiatry, 2020, vol. 11, p. -

Sustained anxiety is a key symptom of anxiety disorders and may be associated with neural activation in the right inferior parietal lobe (rIPL), particularly under unpredictable threat. This finding suggests a moderating role of the rIPL in sustained anxiety, which we tested in the current study. We applied cathodal or sham transcranial direct current stimulation (tDCS) to the rIPL as a...

Université de Fribourg

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens

Rodriguez-Barbosa, Jose-Ignacio ; Schneider, Pascal ; Graca, Luis ; Bühler, Leo ; Perez-Simon, Jose-Antonio ; Rio, Maria-Luisa del

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...

Université de Fribourg

Platelet transforming growth factor-β1 induces liver sinusoidal endothelial cells to secrete interleukin-6

Balaphas, Alexandre ; Meyer, Jeremy ; Perozzo, Remo ; Zeisser-Labouebe, Magali ; Berndt, Sarah ; Turzi, Antoine ; Fontana, Pierre ; Scapozza, Leonardo ; Gonelle-Gispert, Carmen ; Bühler, Leo H.

In: Cells, 2020, vol. 9, no. 5, p. 1311

The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleukin-6 (IL-6), a cytokine implicated in the early phase of liver regeneration....

Université de Fribourg

Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation

Meyer, Jeremy ; Balaphas, Alexandre ; Fontana, Pierre ; Morel, Philippe ; Robson, Simon C. ; Sadoul, Karin ; Gonelle-Gispert, Carmen ; Bühler, Léo

In: Cells, 2020, vol. 9, no. 5, p. 1243

Background: Platelets were postulated to constitute the trigger of liver regeneration. The aim of this study was to dissect the cellular interactions between the various liver cells involved in liver regeneration and to clarify the role of platelets. (2) Methods: Primary mouse liver sinusoidal endothelial cells (LSECs) were co-incubated with increasing numbers of resting platelets, activated...

Université de Fribourg

Improving the assessment of communication competencies in a national licensing OSCE: lessons learned from an experts’ symposium

Monti, Matteo ; Klöckner-Cronauer, * , Christina ; Hautz, Stephanie C. ; Schnabel, Kai P. ; Breckwoldt, Jan ; Junod-Perron, Noëlle ; Feller, Sabine ; Bonvin, Raphael ; Huwendiek, Sören

In: BMC Medical Education, 2020, vol. 20, no. 1, p. 171

Background: As the communication competencies of physicians are crucial for providing optimal patient care, their assessment in the context of the high-stakes Objective Structured Clinical Examination (OSCE) is of paramount importance. Despite abundant literature on the topic, evidence-based recommendations for the assessment of communication competencies in high stakes OSCEs are scarce. As ...

Université de Fribourg

Impossibility results on stability of phylogenetic consensus methods

Delucchi, Emanuele ; Hoessly, Linard ; Paolini, Giovanni

In: Systematic Biology, 2020, vol. 69, no. 3, p. 557–565

We answer two questions raised by Bryant, Francis, and Steel in their work on consensus methods in phylogenetics. Consensus methods apply to every practical instance where it is desired to aggregate a set of given phylogenetic trees (say, gene evolution trees) into a resulting, “consensus” tree (say, a species tree). Various stability criteria have been explored in this context, seeking...

Université de Fribourg

Seismic monitoring in the Gugla rock glacier (Switzerland): ambient noise correlation, microseismicity and modelling

Guillemot, Antoine ; Helmstetter, Agnès ; Larose, Éric ; Baillet, Laurent ; Garambois, Stéphane ; Mayoraz, Raphaël ; Delaloye, Reynald

In: Geophysical Journal International, 2020, vol. 221, no. 3, p. 1719–1735

A network of seismometers has been installed on the Gugla rock glacier since October 2015 to estimate seismic velocity changes and detect microseismicity. These two processes are related to mechanical and structural variations occurring within the rock glacier. Seismic monitoring thus allows a better understanding of the dynamics of rock glaciers throughout the year. We observed seasonal...