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Université de Fribourg

Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity

Kuhn, Benjamin M. ; Nodzyński, Tomasz ; Errafi, Sanae ; Bucher, Rahel ; Gupta, Shibu ; Aryal, Bibek ; Dobrev, Petre ; Bigler, Laurent ; Geisler, Markus ; Zažímalová, Eva ; Friml, Jiří ; Ringli, Christoph

In: Scientific Reports, 2017, vol. 7, p. 41906

The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of transporters such as AUX1/LAX, PIN, and ABCB proteins, and their localization and activity is thought to be influenced by phosphatases and kinases. Flavonols have been shown to alter auxin transport activity and changes in...

Université de Fribourg

Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats

Bahi, Amine ; Dreyer, Jean-Luc

In: Psychopharmacology, 2017, p. 1–12

Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays a fundamental role in the nervous system. Recent research has suggested that this transcription factor is associated with the pathophysiology of psychiatric disorders including addiction, schizophrenia, and depression. However, the role of MyT1 in anxiety- and ethanol-related behaviors is still...

Université de Fribourg

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50

Kvainickas, Arunas ; Orgaz, Ana Jimenez ; Nägele, Heike ; Diedrich, Britta ; Heesom, Kate J. ; Dengjel, Jörn ; Cullen, Peter J. ; Steinberg, Florian

In: J Cell Sci, 2017, vol. 130, no. 2, p. 382–395

Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-domain-containing protein 50 (ANKRD50). ...

Université de Fribourg

Roles of mitophagy in cellular physiology and development

Dengjel, Jörn ; Abeliovich, Hagai

In: Cell and Tissue Research, 2017, vol. 367, no. 1, p. 95–109

The autophagic degradation of mitochondria, or mitophagy, has been shown to occur in eukaryotic cells under various physiological conditions. Broadly, these fall into two categories: quality-control related mitophagy and developmentally induced mitophagy. Quality-control related mitophagy, which is the lysosomal/vacuolar degradation of malfunctioning or superfluous mitochondria, is an...

Université de Fribourg

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition

Diedrich, Britta ; Rigbolt, Kristoffer TG ; Röring, Michael ; Herr, Ricarda ; Kaeser‐Pebernard, Stephanie ; Gretzmeier, Christine ; Murphy, Robert F ; Brummer, Tilman ; Dengjel, Jörn

In: The EMBO Journal, 2017, vol. 36, no. 5, p. 646–663

As a central element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in development and homeostasis and represents the most frequently mutated kinase in tumors. Consequently, it has emerged as an important therapeutic target in various malignancies. Nevertheless, the BRAF activation cycle still raises many mechanistic questions as illustrated by the paradoxical...

Université de Fribourg

Scientific and normative foundations for the valuation of alien-species impacts: thirteen core principles

Essl, Franz ; Hulme, Philip E. ; Jeschke, Jonathan M. ; Keller, Reuben ; Pyšek, Petr ; Richardson, David M. ; Saul, Wolf-Christian ; Bacher, Sven ; Dullinger, Stefan ; Estévez, Rodrigo A. ; Kueffer, Christoph ; Roy, Helen E. ; Seebens, Hanno ; Rabitsch, Wolfgang

In: BioScience, 2017, vol. 67, no. 2, p. 166–178

Biological invasions cause many impacts that differ widely in how they are perceived. We argue that many conflicts in the valuation of the impacts of alien species are attributable to differences in the framing of the issue and implicit assumptions—such conflicts are often not acknowledged. We present 13 principles that can help guide valuation and therefore inform the management of alien...

Université de Fribourg

REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

Chavan, Rohit ; Preitner, Nadia ; Okabe, Takashi ; Mansencal Strittmatter, Laureen ; Xu, Cheng ; Ripperger, Jürgen A. ; Pitteloud, Nelly ; Albrecht, Urs

In: Biology Open, 2017, vol. 6, no. 1, p. 1–7

The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of...

Université de Fribourg

Rev‐erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice

Feillet, Céline A. ; Bainier, Claire ; Mateo, Maria ; Blancas-Velázquez, Aurea ; Salaberry, Nora L. ; Ripperger, Jürgen A. ; Albrecht, Urs ; Mendoza, Jorge

In: Addiction Biology, 2017, vol. 22, no. 2, p. 411–422

The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are driven by the brain suprachiasmatic clock. How the circadian clock impacts on...

Université de Fribourg

Molecular mechanisms in mood regulation involving the circadian clock

Albrecht, Urs

In: Frontiers in Neurology, 2017, vol. 8, p. -

The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment. Disruption of the circadian system, due to irregular lifestyle such as rotating shift work, frequent travel across time-zones, or chronic stress, is correlated with several diseases such as obesity, cancer, and neurological...