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The oral commensal Streptococcus mitis shows a mixed memory Th cell signature that is similar to and cross-reactive with Streptococcus pneumoniae

Engen, Stian André ; Rukke, Håkon Valen ; Becattini, Simone ; Jarrossay, David ; Blix, Inger Johanne ; Petersen, Fernanda Cristina ; Sallusto, Federica ; Schenck, Karl

In: Plos one, 2017, vol. 9, no. 8, p. e104306

Background: Carriage of and infection with Streptococcus pneumoniae is known to predominantly induce T helper 17 (Th17) responses in humans, but the types of Th cells showing reactivity towards commensal streptococci with low pathogenic potential, such as the oral commensals S. mitis and S. salivarius, remain uncharacterized. Methods: Memory CD4+ T helper (Th) cell subsets were isolated from...

Restoration of replication fork stability in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers

Taglialatela, Angelo ; Alvarez, Silvia ; Leuzzi, Giuseppe ; Sannino, Vincenzo ; Ranjha, Lepakshi ; Huang, Jen-Wei ; Madubata, Chioma ; Anand, Roopesh ; Levy, Brynn ; Rabadan, Raul ; Cejka, Petr ; Costanzo, Vincenzo ; Ciccia, Alberto

In: Molecular Cell, 2017, vol. 68, no. 2, p. 414-430.e8

To ensure the completion of DNA replication and maintenance of genome integrity, DNA repair factors protect stalled replication forks upon replication stress. Previous studies have identified a critical role for the tumor suppressors BRCA1 and BRCA2 in preventing the degradation of nascent DNA by the MRE11 nuclease after replication stress. Here we show that depletion of SMARCAL1, a...

Main steps in DNA double-strand break repair : An introduction to homologous recombination and related processes

Ranjha, Lepakshi ; Howard, Sean Michael ; Cejka, Petr

In: Chromosoma, 2018, vol. 127, no. 2 (June), p. 187–214

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation, chemicals or result from faulty DNA metabolic processes. DNA breaks can also be introduced in a programmed manner, such as during the maturation of the immune system, meiosis or cancer chemo- or radiotherapy. Cells have developed a variety of repair pathways, which are fine-tuned to the specific needs of a cell....

Nutritional status does not explain the increase of carotenoid-based coloration associated with age in Great Tits Parus major

Giraudeau, Mathieu ; Barcelo, Margarida ; Senar, Juan

In: Journal of Ornithology, 2014, vol. 155, no. 4, p. 1063-1066

Clinical, laboratory and pathological findings in cats experimentally infected with Aelurostrongylus abstrusus

Schnyder, M. ; Di Cesare, A. ; Basso, W. ; Guscetti, F. ; Riond, B. ; Glaus, T. ; Crisi, P. ; Deplazes, P.

In: Parasitology Research, 2014, vol. 113, no. 4, p. 1425-1433

An experimental test in Mallards ( Anas platyrhynchos ) of the effect of incubation and maternal preen oil on eggshell microbial load

Giraudeau, M. ; Czirják, G. ; Duval, C. ; Bretagnolle, V. ; Gutierrez, C. ; Heeb, P.

In: Journal of Ornithology, 2014, vol. 155, no. 3, p. 671-677

Comparison of calculation methods used for the determination of anthelmintic resistance in sheep in a temperate continental climate

Falzon, L. ; van Leeuwen, J. ; Menzies, P. ; Jones-Bitton, A. ; Sears, W. ; Jansen, J. ; Peregrine, A.

In: Parasitology Research, 2014, vol. 113, no. 6, p. 2311-2322

A Proposal for a Bohmian Ontology of Quantum Gravity

Vassallo, Antonio ; Esfeld, Michael

In: Foundations of Physics, 2014, vol. 44, no. 1, p. 1-18

An exceptionally well-preserved skeleton of Palaeothentes from the Early Miocene of Patagonia, Argentina: new insights into the anatomy of extinct paucituberculatan marsupials

Forasiepi, Analia ; Sánchez-Villagra, Marcelo ; Schmelzle, Thomas ; Ladevèze, Sandrine ; Kay, Richard

In: Swiss Journal of Palaeontology, 2014, vol. 133, no. 1, p. 1-21

Gewinnung haploider Stammzellkulturen der Maus für genetische Screens

Freimann, Remo ; Kramer, Stefan ; Böhmler, Andreas ; Wutz, Anton

In: BIOspektrum, 2014, vol. 20, no. 4, p. 416-418