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Université de Fribourg

Cross-resistance to human cationic antimicrobial peptides and to polymyxins mediated by the plasmid-encoded MCR-1?

Dobias, Jan ; Poirel, Laurent ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2017, p. -

To evaluate whether acquired resistance to cationic antimicrobial peptides (CAMP) group molecules, being normal components of the human immune system, may select co-resistance to antibiotic peptides such as polymyxins, considering they share the same mechanism of action. We aimed to evaluate strains producing the recently identified plasmid-encoded polymyxin resistance determinant MCR-1,...

Université de Fribourg

Nutrition, movement and sleep behaviours: their interactions in pathways to obesity and cardiometabolic diseases

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre

In: Obesity Reviews, 2017, vol. 18, no. S1, p. 3–6

Among the multitude of dietary and lifestyle behaviours that have been proposed to contribute to the obesity epidemic, those that have generated considerable research scrutiny in the past decade are centred upon sleep behaviours, sedentary behaviours (sitting or lying while awake) and diminished low-level physical activities of everyday life, with each category of behaviours apparently...

Université de Fribourg

The ‘when’ and the ‘where’ of single‐trial allocentric spatial memory performance in young children: Insights into the development of episodic memory

Ribordy Lambert, Farfalla ; Lavenex, Pierre ; Lavenex, Pamela Banta

In: Developmental Psychobiology, 2017, vol. 59, no. 2, p. 185–196

Allocentric spatial memory, “where” with respect to the surrounding environment, is one of the three fundamental components of episodic memory: what, where, when. Whereas basic allocentric spatial memory abilities are reliably observed in children after 2 years of age, coinciding with the offset of infantile amnesia, the resolution of allocentric spatial memory acquired over repeated...

Université de Fribourg

Passive and active roles of fat-free mass in the control of energy intake and body composition regulation

Dulloo, Abdul G. ; Jacquet, Jean ; Miles-Chan, Jennifer L ; Schutz, Yves

In: European Journal of Clinical Nutrition, 2017, vol. 71, no. 3, p. 353–357

While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body’s long-term energy requirements and energy intake, the available evidence suggests that the lean body or fat-free mass (FFM) also plays a role in the drive to eat. A distinction must, however, be made between a ‘passive’ role of FFM in driving energy intake,...

Université de Fribourg

Neural reorganization due to neonatal amygdala lesions in the Rhesus monkey: changes in morphology and network structure

Grayson, D. S. ; Bliss-Moreau, E. ; Bennett, J. ; Lavenex, Pierre ; Amaral, David G.

In: Cerebral Cortex, 2017, p. 1–14

It is generally believed that neural damage that occurs early in development is associated with greater adaptive capacity relative to similar damage in an older individual. However, few studies have surveyed whole brain changes following early focal damage. In this report, we employed multimodal magnetic resonance imaging analyses of adult rhesus macaque monkeys who had previously undergone...

Université de Fribourg

Polyunsaturated fatty acids stimulate de novo lipogenesis and improve glucose homeostasis during refeeding with high fat diet

Crescenzo, Raffaella ; Mazzoli, Arianna ; Cancelliere, Rosa ; Bianco, Francesca ; Giacco, Antonia ; Liverini, Giovanna ; Dulloo, Abdul G. ; Iossa, Susanna

In: Frontiers in Physiology, 2017, vol. 8, p. -

The recovery of body weight after a period of caloric restriction is accompanied by an enhanced efficiency of fat deposition and hyperinsulinemia—which are exacerbated by isocaloric refeeding on a high fat diet rich in saturated and monounsaturated fatty acids (SFA-MUFA), and poor in polyunsaturated fatty acids (PUFA), and associated with a blunting of de novo lipogenesis in adipose tissue...

Université de Fribourg

Successful neuropsychological rehabilitation in a patient with Cerebellar Cognitive Affective Syndrome

Ruffieux, N. ; Colombo, Françoise ; Gentaz, E. ; Annoni, Jean-Marie ; Chouiter, Leila ; Roulin Hefti, S. ; Ruffieux, A. ; Bihl, T.

In: Applied Neuropsychology: Child, 2017, vol. 6, no. 2, p. 180–188

The objective of this case study was to describe the neuropsychological rehabilitation of a 16-year-old patient who presented a Cerebellar Cognitive Affective Syndrome (CCAS) following a bilateral cerebellar hemorrhage. The patient presented severe and diffuse cognitive deficits, massive behavioral disorders, and emotion regulation difficulties. The cognitive rehabilitation was performed in...

Université de Fribourg

Area minimizing discs in metric spaces

Lytchak, Alexander ; Wenger, Stefan

In: Archive for Rational Mechanics and Analysis, 2017, vol. 223, no. 3, p. 1123–1182

We solve the classical problem of Plateau in the setting of proper metric spaces. Precisely, we prove that among all disc-type surfaces with prescribed Jordan boundary in a proper metric space there exists an area minimizing disc which moreover has a quasi-conformal parametrization. If the space supports a local quadratic isoperimetric inequality for curves we prove that such a solution is...

Université de Fribourg

Shapes of polyhedra, mixed volumes and hyperbolic geometry

Fillastre, François ; Izmestiev, Ivan

In: Mathematika, 2017, vol. 63, no. 1, p. 124–183

We generalize to higher dimensions the Bavard–Ghys construction of the hyperbolic metric on the space of polygons with fixed directions of edges. The space of convex d -dimensional polyhedra with fixed directions of facet normals has a decomposition into type cones that correspond to different combinatorial types of polyhedra. This decomposition is a subfan of the secondary fan of a vector...

Université de Fribourg

Classification of flexible Kokotsakis polyhedra with quadrangular base

Izmestiev, Ivan

In: International Mathematics Research Notices, 2017, vol. 2017, no. 3, p. 715–808

A Kokotsakis polyhedron with quadrangular base is a neighborhood of a quadrilateral in a quad surface. Generically, a Kokotsakis polyhedron is rigid. In this article we classify flexible Kokotsakis polyhedra with quadrangular bases. The analysis is based on the fact that any pair of adjacent dihedral angles of a Kokotsakis polyhedron is related by a biquadratic equation. This results in a diagram...