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Université de Fribourg

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Mottas, Inès ; Bekdemir, Ahmet ; Cereghetti, Alessandra ; Spagnuolo, Lorenzo ; Yang, Yu-Sang Sabrina ; Müller, Marie ; J.Irvine, Darrell ; Stellaccic, Francesco ; Bourquin, Carole

In: Biomaterials, 2019, vol. 190–191, p. 111–120

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune response is initiated, is key. Efforts to use nanoparticles as carriers for cancer immunotherapy have generally required targeting agents and...

Université de Fribourg

The diffeomorphism type of small hyperplane arrangements is combinatorially determined

Gallet, Matteo ; Saini, Elia

In: Advances in Geometry, 2019, vol. 19, no. 1, p. 89–100

It is known that there exist hyperplane arrangements with the same underlying matroid that admit non-homotopy equivalent complement manifolds. Here we show that, in any rank, complex central hyperplane arrangements with up to 7 hyperplanes and the same underlying matroid are isotopic. In particular, the diffeomorphism type of the complement manifold and the Milnor fiber and fibration of these...

Université de Fribourg

A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs

Fernandez, Aurore ; Kirsch, Irving ; Noël, Louis ; Rodondi, Pierre Yves ; Kaptchuk, Ted J. ; Suter, Marc R. ; Décosterd, Isabelle ; Berna, Chantal

In: PLOS ONE, 2019, vol. 14, no. 1, p. e0209851

Side effects are frequent in pharmacological pain management, potentially preceding analgesia and limiting drug tolerability. Discussing side effects is part of informed consent, yet can favor nocebo effects. This study aimed to test whether a positive suggestion regarding side effects, which could act as reminders of the medication having been absorbed, might favor analgesia in a clinical...

Université de Fribourg

3D morphology of pharyngeal dentition of the genus Capoeta (Cyprinidae): Implications for taxonomy and phylogeny

Ayvazyan, Anna ; Vasilyan, Davit ; Böhme, Madelaine

In: Journal of Zoological Systematics and Evolutionary Research, 2019, vol. 57, no. 1, p. 179–190

Capoeta is a herbivorous cyprinid fish genus, widely distributed in water bodies of Western Asia. Recent species show a distinct biogeographic pattern with endemic distribution in large fluvial drainage basins. As other cyprinids, the species of this genus are characterized by the presence of the pharyngeal bone with pharyngeal teeth. Despite this, the detailed morphology of the pharyngeal...

Université de Fribourg

The role of glacier retreat for Swiss hydropower production

Schaefli, Bettina ; Manso, Pedro ; Fischerc, Mauro ; Huss, Matthias ; Farinotti, Daniel

In: Renewable Energy, 2019, vol. 132, p. 615–627

High elevation or high latitude hydropower production (HP) strongly relies on water resources that are influenced by glacier melt and are thus highly sensitive to climate warming. Despite of the wide-spread glacier retreat since the development of HP infrastructure in the 20th century, little quantitative information is available about the role of glacier mass loss for HP. In this paper, we...

Université de Fribourg

Global glacier volume projections under high-end climate change scenarios

Shannon, Sarah ; Smith, Robin ; Wiltshire, Andy ; Payne, Tony ; Huss, Matthias ; Betts, Richard ; Caesar, John ; Koutroulis, Aris ; Jones, Darren ; Harrison, Stephan

In: The Cryosphere, 2019, vol. 13, no. 1, p. 325–350

The Paris agreement aims to hold global warming to well below 2 ∘C and to pursue efforts to limit it to 1.5 ∘C relative to the pre-industrial period. Recent estimates based on population growth and intended carbon emissions from participant countries suggest global warming may exceed this ambitious target. Here we present glacier volume projections for the end of this century, under a...

Université de Fribourg

Surviving in the BRICS: the struggle of South African business in coping with new partners and investors

Wenzel, Nadine ; Freund, Bill ; Graefe, Olivier

In: International Review of Applied Economics, 2019, vol. 33, no. 1, p. 51–70

The purpose of this paper is to improve our understanding of how South African economic actors react to the gradual entry of non-South African BRICS firms in their established business areas. Throughout the twentieth century, South Africa’s trade and investment activities were conducted overwhelmingly with Western countries. However, the end of apartheid coincided with significant shifts as...