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Université de Fribourg

Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system

Loffing-Cueni, Dominique ; Flores, Sandra Y. ; Sauter, Daniel ; Daidié, Dorothée ; Siegrist, Nicole ; Meneton, Pierre ; Staub, Olivier ; Loffing, Johannes

In: Journal of the American Society of Nephrology, 2006, vol. 17, p. 1264-1274

The activity of the epithelial sodium (Na⁺) channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) needs to be tightly regulated to match urinary Na⁺ excretion with dietary Na⁺ intake. The ubiquitin-protein ligase Nedd4-2, which in vitro interacts with ENaC subunits and reduces ENaC cell surface abundance and activity by ubiquitylation of the channel, may participate in...

Université de Fribourg

Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E ; Rouiller, Eric M

In: Nature Medicine, 2006/12/

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A–specific antibody as compared to monkeys treated with control...

Université de Fribourg

Spatial relational memory in 9-month-old macaque monkeys

Lavenex, Pierre ; Lavenex, Pamela Banta

In: Learning & Memory, 2006, vol. 13, p. 84-96

This experiment assesses spatial and nonspatial relational memory in freely moving 9-mo-old and adult (11-13-yr-old) macaque monkeys (Macaca mulatta). We tested the use of proximal landmarks, two different objects placed at the center of an open-field arena, as conditional cues allowing monkeys to predict the location of food rewards hidden in one of two sets of three distinct locations....

Université de Fribourg

Hippocampal lesion prevents spatial relational learning in adult Macaque monkeys

Lavenex, Pamela Banta ; Amaral, David G. ; Lavenex, Pierre

In: The Journal of Neuroscience, 2006, vol. 26(17), p. 4546-4558

The role of the hippocampus in spatial learning and memory has been extensively studied in rodents. Comparable studies in nonhuman primates, however, are few, and findings are often contradictory. This may be attributable to the failure to distinguish between allocentric and egocentric spatial representations in experimental designs. For this experiment, six adult monkeys received bilateral...

Université de Fribourg

Corticotropin-Releasing Hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Smith, S. R. ; Dulloo, Abdul G.

In: Endocrinology, 2006, vol. 147(1), p. 31-38

The mechanisms by which CRH and related peptides (i.e. the CRH/urocortin system) exert their control over thermogenesis and weight regulation have until now focused only upon their effects on brain centers controlling sympathetic outflow. Using a method that involves repeated oxygen uptake determinations in intact mouse skeletal muscle, we report here that CRH can act directly on skeletal...

Université de Fribourg

Interventions : une étude expérimentale et analogue de différentes formes d'interventions

Montini Lirrg, Patrizia ; Reicherts, Michaël (Dir.) ; Perrez, Meinrad (Codir.)

Thèse de doctorat : Université de Fribourg, 2005.

Cette étude est réalisée dans le cadre de la recherche sur les processus psychothérapeutiques et leurs effets, en fonction de différentes formes d’interventions approfondissantes. De plus, elle tient compte des caractéristiques préalables du client susceptibles de modérer l’impact cognitif et émotionnel de ces interventions. Dans cette étude expérimentale et analogue, on applique...

Université de Neuchâtel

An elicitor in caterpillar oral secretions that induces corn seedlings to emit chemical signals attractive to parasitic wasps

Turlings, Ted C. J. ; McCall, Philip J. ; Alborn, Hans ; Tumlinson, James H.

In: Journal of Chemical Ecology, 1993, vol. 19, p. 411 - 425

Regurgitate of corn-fed beet armyworm (BAW) caterpillars, Spodoptera exigua, when applied to damaged sites of corn (Zea mays) seedlings, causes the release of relatively large amounts of terpenes by the seedlings several hours later. This plant response could be induced by merely placing the cut stem of seedlings in a solution of BAW regurgitate for 12 hr, a response that could not...

Université de Neuchâtel

Isolation and identification of allelochemicals that attract the larval parasitoid, Cotesia marginiventris (Cresson), to the microhabitat of one of its hosts

Turlings, Ted C. J. ; Tumlinson, James H. ; Heath, Robert R. ; Proveaux, Adron T. ; Doolittle, Robert E.

In: Journal of Chemical Ecology, 1991, vol. 17, p. 2235-2250

Volatiles released from corn seedlings on which beet armyworm larvae were feeding were attractive to females of the parasitoid, Cotesia marginiventris (Cresson), in flight tunnel bioassays. Analyses of the collected volatiles revealed the consistent presence of 11 compounds in significant amounts. They were: (Z)-3-hexenal, (E)-2-hexenal, (Z)-3-hexen-1-ol, (Z)- 3-hexen-1-yl acetate,...

Université de Fribourg

Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity

Dulloo, Abdul G.

In: Hormone Research, 2006, vol. 65(suppl 3), p. 90–97

Catch-up growth during infancy and childhood is increasingly recognized as a major risk factor for later development of insulin-related complications and chronic diseases, namely abdominal obesity, type 2 diabetes and cardiovascular disease. As catch-up growth per se is characterized by insulin resistance, hyperinsulinaemia and an accelerated rate of fat storage (i.e., catch-up fat) even in the...