In: Nature communications, 2018, vol. 9, p. 4016
DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods, we show that phosphorylation of Saccharomyces cerevisiae Sae2 controls its capacity to promote the Mre11-Rad50-Xrs2 (MRX) nuclease to...
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In: Glycobiology, 1999, vol. 9, no. 5, p. 435-441
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In: Nucleic Acids Research, 1997, vol. 25, no. 24, p. 5052-5056
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In: Nucleic Acids Research, 2015, vol. 43, no. 6, p. 3344-3357
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In: Nucleic Acids Research, 2014, vol. 42, no. 21, p. 13353-13369
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In: Nucleic Acids Research, 1997, vol. 25, no. 12, p. 2375-2380
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In: Nucleic Acids Research, 1999, vol. 27, no. 16, p. 3245-3252
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In: Cancer Discovery, 2012, vol. 2, no. 3, p. 248-259
Metastatic breast tumor cells display an epithelial–mesenchymal transition (EMT) that increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 has been shown to contribute to EMT and cancer metastasis, the signaling pathways regulating Twist1 activity are poorly understood. Here, we show that Twist1 is ubiquitously phosphorylated in 90% of 1,532 invasive...
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