Università della Svizzera italiana

Targeting glycolysis in macrophages confers protection against pancreatic ductal adenocarcinoma

Penny, Hweixian Leong ; Sieow, Je Lin ; Gun, Sin Yee ; Lau, Mai Chan ; Lee, Bernett ; Tan, Jasmine ; Phua, Cindy ; Toh, Florida ; Nga, Yvonne ; Yeap, Wei Hseun ; Janela, Baptiste ; Kumar, Dilip ; Chen, Hao ; Yeong, Joe ; Kenkel, Justin A. ; Pang, Angela ; Lim, Diana ; Toh, Han Chong ; Hon, Tony Lim Kiat ; Johnson, Christopher I. ; Khameneh, Hanif Javanmard ; Mortellaro, Alessandra ; Engleman, Edgar G. ; Rotzschke, Olaf ; Ginhoux, Florent ; Abastado, Jean-Pierre ; Chen, Jinmiao ; Wong, Siew Cheng

In: International journal of molecular sciences, 2021, vol. 22, no. 12, p. 24

Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage- specific deletion of Glucose Transporter 1...

Université de Fribourg

The auxin influx carrier, OsAUX3, regulates rice root development and responses to aluminium stress

Wang, Mei ; Qiao, JiYue ; Yu, ChenLiang ; Chen, Hao ; Sun, ChenDong ; Huang, LinZhou ; Li, ChuanYou ; Geisler, Markus ; Qian, Qian ; Jiang, De An ; Qi, YanHua

In: Plant, Cell & Environment, 2019, vol. 42, no. 4, p. 1125–1138

In rice, there are five members of the auxin carrier AUXIN1/LIKE AUX1 family; however, the biological functions of the other four members besides OsAUX1 remain unknown. Here, by using CRISPR/Cas9, we constructed two independent OsAUX3 knock‐down lines, osaux3‐1 and osaux3‐2, in wild‐type rice, Hwayoung (WT/HY) and Dongjin (WT/DJ). osaux3‐1 and osaux3‐2 have shorter primary roots...