In: Journal of Neurovirology, ///-
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In: mSphere, 2018, vol. 3, no. 1, p. e00518-17
Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross- protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate that, although rare, antibodies to conserved GII.4 blockade epitopes are generated. The mechanisms by...
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In: BMC immunology, 2014, vol. 15, p. 14
Background: MicroRNAs (miRNAs) are short non-coding RNAs involved in the posttranscriptional regulation of a wide range of biological processes. By binding to complementary sequences on target messenger RNAs, they trigger translational repression and degradation of the target, eventually resulting in reduced protein output. MiRNA-dependent regulation of protein translation is a very widespread...
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In: Evolutionary Ecology, 2007, vol. 21, no. 4, p. 473-483
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