In: Journal of Inorganic Biochemistry, 2020, vol. 209, p. 111122
A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2′-bipyridine and 5- ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing molecules...
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In: Advanced Sustainable Systems, 2020, vol. 4, no. 1, p. 1900101
Polydopamine can form black nanoparticles and has recently been gaining attention due to its extraordinary heating properties upon excitation with light. Herein, polydopamine hybrid nanoparticles are synthesized in different sizes and subsequently added to a solar fluid to analyze heating ability. The solar fluids with the differently sized hybrid polydopamine particles are compared to a...
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In: Biomacromolecules, 2018, vol. 19, no. 9, p. 3693–3704
The oxidation of dopamine and of other catecholamines leads to the formation of conformal films on the surface of all known materials and to the formation of a precipitate in solution. In some cases, it has been shown that the addition of additives in the dopamine solution, like certain surfactants or polymers, polyelectrolytes, and certain proteins, allows to get polydopamine nanoparticles...
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In: Advanced Materials, 2018, p. -
Realization of the immense potential of nanomaterials for biomedical applications will require a thorough understanding of how they interact with cells, tissues, and organs. There is evidence that, depending on their physicochemical properties and subsequent interactions, nanomaterials are indeed taken up by cells. However, the subsequent release and/or intracellular degradation of the...
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In: ACS Applied Materials & Interfaces, 2017, vol. 9, no. 22, p. 18501–18511
A major hurdle in the development of biomedical nanoparticles (NP) is understanding how they interact with complex biological systems and navigate biological barriers to arrive at pathological targets. It is becoming increasingly evident that merely controlling particle physicochemical properties may not be sufficient to mediate particle biodistribution in dynamic environments. Thus,...
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In: Dalton Transactions, 2017, vol. 46, no. 7, p. 2159–2164
Herein we report the synthesis of new water-soluble vitamin B12 prodrugs bearing metal complexes at the β-upper side of the cobalt center. A total of three derivatives with the general design {Co–C[triple bond, length as m-dash]C-bpy–M}, where M represents a cytotoxic metal complex, were prepared and tested for their cytotoxicity against MCF-7 breast cancer cells. The choice of the metal...
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