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Université de Fribourg

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes

Xue, Gongda ; Restuccia, David F. ; Lan, Qiang ; Hynx, Debby ; Dirnhofer, Stephan ; Hess, Daniel ; Rüegg, Curzio ; Hemmings, Brian A.

In: Cancer Discovery, 2012, vol. 2, no. 3, p. 248-259

Metastatic breast tumor cells display an epithelial–mesenchymal transition (EMT) that increases cell motility, invasion, and dissemination. Although the transcription factor Twist1 has been shown to contribute to EMT and cancer metastasis, the signaling pathways regulating Twist1 activity are poorly understood. Here, we show that Twist1 is ubiquitously phosphorylated in 90% of 1,532 invasive...

Université de Fribourg

Radiation-induced modifications of the tumor microenvironment promote metastasis

Rüegg, Curzio ; Monnier, Yan ; Kuonen, François ; Imaizumi, Natsuko

In: Bulletin du Cancer, 2011, vol. 98, no. 6, p. 47-57

Radiotherapy is successfully used to treat cancer. Emerging evidence, however, indicates that recurrences after radiotherapy are associated with increased local invasion, metastatic spreading and poor prognosis. Radiation-induced modifications of the tumor microenvironment have been proposed to contribute to increased aggressive tumor behavior, an effect also referred to as tumor bed effect, but...

Université de Fribourg

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging : Preclinical investigation and dosimetry

Buchegger, F. ; Viertl, D. ; Baechler, Sébastien ; Dunet, V. ; Kosinski, M. ; Poitry-Yamate, C. ; Rüegg, Curzio ; Prior, J. O.

In: Nuklearmedizin, 2011, vol. 50, no. 6, p. 221-246

Aim: To visualize neovasculature and/or tumour integrin αvβ3 we selected the binding moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68Ga. Methods: NODAGA-RGDyK (ABX) was labeled with the 68Ga eluate from the 68Ge generator IGG100 using the processor unit PharmTracer. Biodistribution was measured in female Hsd mice sacrificed 10, 30, 60 and 90 min after i.v. injection...

Université de Fribourg

Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells

Laurent, Julien ; Touvrey, Cédric ; Botta, Francesca ; Kuonen, François ; Rüegg, Curzio

In: The International Journal of Developmental Biology, 2011, vol. 55, p. 527-534

Cancer-related inflammation has emerged in recent years as a major event contributing to tumor angiogenesis, tumor progression and metastasis formation. Bone marrow-derived and inflammatory cells promote tumor angiogenesis by providing endothelial progenitor cells that differentiate into mature endothelial cells, and by secreting pro-angiogenic factors and remodeling the extracellular matrix...

Université de Fribourg

Autologous stem cell transplantation: leukapheresis product has anti-angiogenic effects in vivo correlating with neutrophil-derived VEGFR1

Luethy, Anita ; Stenner, Frank ; Lohri, Corinne ; Muller, Christoph ; Samaras, Panagiotis ; Steiner, Rudolf ; Broek, Maries Van Den ; Mischo, Axel ; Renner, Christoph ; Knuth, Alexander ; Rüegg, Curzio ; Wenger, Roland H. ; Zweifel, Martin

In: Anticancer Research, 2011, vol. 31, no. 10, p. 3115-3124

Background: High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) is used for the treatment of hemato-oncologic malignancies. In this study, we measured the effect of HDC/ASCT on plasma concentrations of antiangiogenic soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and of leukapheresis products (LP) and patient serum on chick chorioallantoic...

Université de Fribourg

Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells

Zaric, J. ; Joseph, J.-M. ; Tercier, S. ; Sengstag, T. ; Ponsonnet, L. ; Delorenzi, M. ; Rüegg, Curzio

In: Oncogene, 2012, vol. 31, p. 48-59

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors (COXIBs) reduces the risk of cancer development and progression, in particular of the colon. The COXIB...

Université de Fribourg

MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells

Carrascosa, C. ; Obula, R. G. ; Missiaglia, E. ; Lehr, H.-A. ; Delorenzi, M. ; Frattini, M. ; Rüegg, Curzio ; Mariotti, Agnese

In: Oncogene, 2011, p. -

Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined mechanisms. By analyzing publicly available gene expression profiles of breast carcinomas, we found that MFG-E8 is highly expressed in primary and metastatic breast carcinomas, associated with absent estrogen receptor expression....

Université de Fribourg

Proangiogenic factor PlGF programs CD11b+ myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors

Laurent, Julien ; Faes-van't Hull, Eveline ; Touvrey, Cedric ; Kuonen, François ; Lan, Qiang ; Lorusso, Girieca ; Doucey, Marie-Agnès ; Ciarloni, Laura ; Imaizumi, Natsuko ; Alghisi, Gian Carlo ; Fagiani, Ernesta ; Zaman, Khalil ; Stupp, Roger ; Shibuya, Masabumi ; Delaloye, Jean-François ; Christofori, Gerhard ; Rüegg, Curzio

In: Cancer Research, 2011, vol. 71, no. 11, p. 3781-3791

Tumor-mobilized bone marrow-derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here we show that CD11b+ myelomonocytic cells develop proangiogenic properties during their differentiation from CD34+ hematopoietic progenitors and that Placenta Growth Factor (PlGF) is critical in promoting this ...

Université de Fribourg

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

Garrido-Urbani, Sarah ; Jemelin, Stephane ; Deffert, Christine ; Carnesecchi, Stéphanie ; Basset, Olivier ; Szyndralewiez, Cédric ; Heitz, Freddy ; Page, Patrick ; Montet, Xavier ; Michalik, Liliane ; Arbiser, Jack ; Rüegg, Curzio ; Krause, Karl Heinz ; Imhof, Beat A.

In: PLoS ONE, 2011, vol. 6, no. 2, p. e14665

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired...

Université de Fribourg

Radiotherapy suppresses angiogenesis in mice through TGF-ßRI/ALK5-dependent inhibition of endothelial cell sprouting

Imaizumi, Natsuko ; Monnier, Yan ; Hegi, Monika ; Mirimanoff, René-Olivier ; Rüegg, Curzio

In: PLoS ONE, 2010, vol. 5, no. 6, p. e11084

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also their angiogenic capacity. In spite of its clinical relevance, such putative anti-angiogenic effect of radiotherapy has not been thoroughly...