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Université de Fribourg

Antimicrobial Resistance in Escherichia coli

Poirel, Laurent ; Madec, Jean-Yves ; Lupo, Agnese ; Schink, Anne-Kathrin ; Kieffer, Nicolas ; Nordmann, Patrice ; Schwarz, Stefan

In: Microbiology Spectrum, 2018, vol. 6, no. 4, p. -

Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic...

Université de Fribourg

Acquisition of extended-spectrum β-lactamase GES-6 leading to resistance to ceftolozane-tazobactam combination in Pseudomonas aeruginosa

Poirel, Laurent ; Ortiz De La Rosa, José-Manuel ; Kieffer, Nicolas ; Dubois, Véronique ; Jayol, Aurélie ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2019, vol. 63, no. 1, p. e01809-18

A clinical Pseudomonas aeruginosa isolate resistant to all β-lactams, including ceftolozane-tazobactam and carbapenems, was recovered. It belonged to sequence type 235 and produced the extended-spectrum β-lactamase (ESBL) GES-6 differing from GES-1 by two amino acid substitutions (E104K and G170S). GES-6 possessed an increased hydrolytic activity toward carbapenems and to ceftolozane and a ...

Université de Fribourg

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Sanz‑Ortega, Laura ; Rojas, José M. ; Marcos, Ana ; Portilla, Yadileiny ; Stein, Jens V. ; Barber, Domingo F.

In: Journal of Nanobiotechnology, 2019, vol. 17, no. 1, p. 14

T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these...

Université de Fribourg

Aging effects on prefrontal cortex oxygenation in a posture-cognition dual-task: an fNIRS pilot study

Marusic, Uros ; Taube, Wolfgang ; Morrison, Shawnda A. ; Biasutti, Lea ; Grassi, Bruno ; Pauw, Kevin De ; Meeusen, Romain ; Pisot, Rado ; Ruffieux, Jan

In: European Review of Aging and Physical Activity, 2019, vol. 16, no. 1, p. 2

The aging process alters upright posture and locomotion control from an automatically processed to a more cortically controlled one. The present study investigated a postural-cognitive dual-task paradigm in young and older adults using functional Near- Infrared Spectroscopy (fNIRS).Methods: Twenty healthy participants (10 older adults 72 ± 3 y, 10 young adults 23 ± 3 y) performed a...

Université de Fribourg

H2S, a Bacterial Defense Mechanism against the Host Immune Response

Toliver-Kinsky, Tracy ; Cui, Weihua ; Törö, Gabor ; Lee, Seung-Jin ; Shatalin, Konstantin ; Nudler, Evgeny ; Szabo, Csaba

In: Infection and Immunity, 2019, vol. 87, no. 1, p. e00272-18

The biological mediator hydrogen sulfide (H2S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H2S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections,...

Université de Fribourg

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

Bibli, Sofia-Iris ; Hu, Jiong ; Sigala, Fragiska ; Wittig, Ilka ; Heidler, Juliana ; Zukunft, Sven ; Tsilimigras, Diamantis I. ; Randriamboavonjy, Voahanginirina ; Wittig, Janina ; Kojonazarov, Baktybek ; Schürmann, Christoph ; Siragusa, Mauro ; Siuda, Daniel ; Luck, Bert ; Malik, Randa Abdel ; Filis, Konstantinos A. ; Zografos, George ; Chen, Chen ; Wang, Dao Wen ; Pfeilschifter, Josef ; Brandes, Ralf P. ; Szabo, Csaba ; Papapetropoulos, Andreas ; Fleming, Ingrid

In: Circulation, 2019, vol. 139, no. 1, p. 101–114

Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control and consequences of CSE activity in endothelial cells under physiological and proatherogenic conditions.

Université de Fribourg

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Mottas, Inès ; Bekdemir, Ahmet ; Cereghetti, Alessandra ; Spagnuolo, Lorenzo ; Yang, Yu-Sang Sabrina ; Müller, Marie ; J.Irvine, Darrell ; Stellaccic, Francesco ; Bourquin, Carole

In: Biomaterials, 2019, vol. 190–191, p. 111–120

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune response is initiated, is key. Efforts to use nanoparticles as carriers for cancer immunotherapy have generally required targeting agents and...

Université de Fribourg

The diffeomorphism type of small hyperplane arrangements is combinatorially determined

Gallet, Matteo ; Saini, Elia

In: Advances in Geometry, 2019, vol. 19, no. 1, p. 89–100

It is known that there exist hyperplane arrangements with the same underlying matroid that admit non-homotopy equivalent complement manifolds. Here we show that, in any rank, complex central hyperplane arrangements with up to 7 hyperplanes and the same underlying matroid are isotopic. In particular, the diffeomorphism type of the complement manifold and the Milnor fiber and fibration of these...

Université de Fribourg

A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs

Fernandez, Aurore ; Kirsch, Irving ; Noël, Louis ; Rodondi, Pierre Yves ; Kaptchuk, Ted J. ; Suter, Marc R. ; Décosterd, Isabelle ; Berna, Chantal

In: PLOS ONE, 2019, vol. 14, no. 1, p. e0209851

Side effects are frequent in pharmacological pain management, potentially preceding analgesia and limiting drug tolerability. Discussing side effects is part of informed consent, yet can favor nocebo effects. This study aimed to test whether a positive suggestion regarding side effects, which could act as reminders of the medication having been absorbed, might favor analgesia in a clinical...