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Elongation factor 1a mediates the specificity of mitochondrial tRNA import in T. brucei

Bouzaidi-Tiali, Nabile ; Aeby, Eric ; Charrière, Fabien ; Pusnik, Mascha ; Schneider, André

In: The EMBO Journal, 2007, vol. 26, no. 20, p. 4302–4312

Mitochondrial tRNA import is widespread in eukaryotes. Yet, the mechanism that determines its specificity is unknown. Previous in vivo experiments using the tRNAsMet, tRNAIle and tRNALys have suggested that the T-stem nucleotide pair 51:63 is the main localization determinant of tRNAs in Trypanosoma brucei. In the cytosol-specific initiator...

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Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest

Chanez, Anne-Laure ; Hehl, Adrian B. ; Engstler, Markus ; Schneider, André

In: Journal of Cell Science, 2006, vol. 119, p. 2968-2974

Mitochondrial fission is mediated by dynamin-like proteins (DLPs). Trypanosoma brucei contains a single DLP, which is the only member of the dynamin superfamily. We have previously shown that expression of the human proapoptotic Bax in T. brucei induces extensive mitochondrial fragmentation. Here we report that Baxinduced mitochondrial fission is abolished in cell lines lacking...

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