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Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)

Wahl, Patricia R. ; Serra, Andreas L. ; Le Hir, Michel ; Molle, Klaus D. ; Hall, Michael N. ; Wüthrich, Rudolf P.

In: Nephrology Dialysis Transplantation, 2006, vol. 21, no. 3, p. 598-604

Nephrotoxicity of rapamycin: an emerging problem in clinical medicine

Marti, Hans-Peter ; Frey, Felix J.

In: Nephrology Dialysis Transplantation, 2005, vol. 20, no. 1, p. 13-15

Perspectives of targeting mTORC1–S6K1 in cardiovascular aging

Ming, Xiu-Fen ; Montani, Jean-Pierre ; Yang, Zhihong

In: Frontiers in Vascular Physiology, 2012, vol. 3, p. 5

The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in...