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The sperm-oocyte switch in the C. elegans hermaphrodite is controlled through steady-state levels of the fem-3 mRNA

Zanetti, Simone ; Grinschgl, Sonja ; Meola, Marco ; Belfiore, Marco ; Rey, Samantha ; Bianchi, Pamela ; Puoti, Alessandro

In: RNA, 2012, vol. 18, no. 7, p. 1385-1394

Post-transcriptional control regulates many aspects of germline development in the Caenorhabditis elegans hermaphrodite. This nematode switches from spermatogenesis to oogenesis and is, therefore, capable of self-fertilization. This sperm-oocyte switch requires 3′ UTR-mediated repression of the fem-3 mRNA. Loss of fem-3 repression results in continuous spermatogenesis in hermaphrodites....