In: International Immunology, 2002, vol. 14, no. 5, p. 503-511
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In: Annals of Oncology, 1997, vol. 8, p. S75-S78
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In: International Immunology, 1991, vol. 3, no. 1, p. 57-66
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In: International Immunology, 1999, vol. 11, no. 12, p. 1971-1980
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Thèse de doctorat : Université de Neuchâtel, 2015.
Cancer is a major cause of morbidity and mortality in today’s world, affecting populations in all countries and all regions. Although no drug or treatment able to cure cancer in all of its forms and variations was found so far, the clinical advancements of 20th and 21st century provided a number of effective drugs for specific types of cancers and had a significant effect...
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In: Angewandte Chemie International Edition, 2014, vol. 53, no. 46, p. 12613–12617
The functionalization of gold nanorods (GNRs) with polymers is essential for both their colloidal stability and biocompatibility. However, a bilayer of the toxic cationic surfactant cetyl trimethylammonium bromide (CTAB) adsorbed on the nanorods complicates this process. Herein, we report on a strategy for the biocompatible functionalization of GNRs with a hydrophobic polymeric precursor,...
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In: ACS Nano, 2011, vol. 5, no. 12, p. 9696–9702
To investigate the potential of DNA origami constructs as programmable and noncytotoxic immunostimulants, we tested the immune responses induced by hollow 30-helix DNA origami tubes covered with up to 62 cytosine-phosphate-guanine (CpG) sequences in freshly isolated spleen cells. Unmethylated CpG sequences that are highly specific for bacterial DNA are recognized by a specialized receptor of the...
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Thèse de doctorat : Université de Neuchâtel, 2010 ; 2190.
Le but de ce travail de thèse a été de développer dans un premier temps des complexes mononucléaires arène-ruthénium à ligands thiolatopyridine et à ligands chélatants 2-(pyridine-2-yl)thiazaole, puis dans un deuxième temps des complexes dinucléaires arène-ruthénium contenant trois ponts thiophénolato ainsi que des complexes dinucléaires de carbonyle-ruthénium à ponts...
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In: Materials, 2011, vol. 4, no. 2, p. 355-367
Biofilm formation on implant materials causes a common problem: resistance to aggressive pharmacological agents as well as host defenses. Therefore, to reduce bacterial adhesion to implant surfaces we propose to use silver(I) coordination networks as it is known that silver is the most powerful antimicrobial inorganic agent. As a model surface, self-assembled monolayers (SAMs) on gold Au(111) was...
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Thèse de doctorat : Université de Neuchâtel, 2010.
Ever since the discovery of cisplatin by Rosenberg in the 1970’s metal complexes as anti-cancer drugs have become an increasing subject of research. Ruthenium as a substitute for the toxic platinum metal has received a lot of attention recently. Organometallic compounds such as arene ruthenium complexes are very versatile and have proven to be active against cancer cells. In order to exploit...
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