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A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Forrester, Alison ; Leonibus, Chiara De ; Grumati, Paolo ; Fasana, Elisa ; Piemontese, Marilina ; Staiano, Leopoldo ; Fregno, Ilaria ; Raimondi, Andrea ; Marazza, Alessandro ; Bruno, Gemma ; Iavazzo, Maria ; Intartaglia, Daniela ; Seczynska, Marta ; van Anken, Eelco ; Conte, Ivan ; De Matteis, Maria Antonietta ; Dikic, Ivan ; Molinari, Maurizio ; Settembre, Carmine

In: The EMBO Journal, 2019, vol. 38, no. 2, p. e99847

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails to attain the native structure is cleared by autophagy. However, how autophagy selectively recognizes misfolded procollagens in the ER lumen is...

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

Schaeffer, Véronique ; Lavenir, Isabelle ; Ozcelik, Sefika ; Tolnay, Markus ; Winkler, David T. ; Goedert, Michel

In: Brain, 2012, vol. 135, no. 7, p. 2169-2177

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

Nascimento-Ferreira, Isabel ; Nóbrega, Clévio ; Vasconcelos-Ferreira, Ana ; Onofre, Isabel ; Albuquerque, David ; Aveleira, Célia ; Hirai, Hirokazu ; Déglon, Nicole ; Pereira de Almeida, Luís

In: Brain, 2013, vol. 136, no. 7, p. 2173-2188

Delayed degradation of chlorophylls and photosynthetic proteins in Arabidopsis autophagy mutants during stress-induced leaf yellowing

Sakuraba, Yasuhito ; Lee, Sang-Hwa ; Kim, Ye-Sol ; Park, Ohkmae K. ; Hörtensteiner, Stefan ; Paek, Nam-Chon

In: Journal Of Experimental Botany, 2014, vol. 65, no. 14, p. 3915-3925

RACK1 is an interaction partner of ATG5 and a novel regulator of autophagy

Erbil, Secil ; Oral, Ozlem ; Mitou, Geraldine ; Kig, Cenk ; Durmaz-Timucin, Emel ; Guven-Maiorov, Emine ; Gulacti, Ferah ; Gokce, Gokcen ; Dengjel, Jörn ; Sezerman, Osman Ugur ; Gozuacik, Devrim

In: Journal of Biological Chemistry, 2016, vol. 291, no. 32, p. 16753–16765

Autophagy is biological mechanism allowing recycling of long-lived proteins, abnormal protein aggregates, and damaged organelles under cellular stress conditions. Following sequestration in double- or multimembrane autophagic vesicles, the cargo is delivered to lysosomes for degradation. ATG5 is a key component of an E3-like ATG12-ATG5-ATG16 protein complex that catalyzes conjugation of the...