Affiner les résultats

Phase Responses to Light Pulses in Mice Lacking Functional per or cry Genes

Spoelstra, Kamiel ; Albrecht, Urs ; Horst, Gijsbertus T. J. van der ; Brauer, Verena ; Daan, Serge

In: Journal of Biological Rhythms, 2004, vol. 19 (6), p. 518-529

The phase-resetting properties of the circadian system in mice with a functional deletion in mCry1, mCry2, mPer1, or mPer2 were studied in 2 experiments. In experiment 1, mCry1-/- and mCry2-/- mice as well as mPer1Brdm1 and mPer2Brdm1 mutant mice were exposed to 15-min light pulses during the 1st cycle following entrainment, either early (external time [ExT] 20) or late (ExT 4) in the subjective...