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Analysis of site-specific N-glycan remodeling in the endoplasmic reticulum and the Golgi

Hang, Ivan ; Lin, Chia-wei ; Grant, Oliver C. ; Fleurkens, Susanna ; Villiger, Thomas K. ; Soos, Miroslav ; Morbidelli, Massimo ; Woods, Robert J. ; Gauss, Robert ; Aebi, Markus

In: Glycobiology, 2015, vol. 25, no. 12, p. 1335-1349

Trafficking of Estrella lausannensis in human macrophages

Rusconi, Brigida ; Kebbi-Beghdadi, Carole ; Greub, Gilbert ; Timms, Peter

In: Pathogens and Disease, 2015, vol. 73, no. 5, p. -

The N-glycosylation defect of cwh8Δ yeast cells causes a distinct defect in sphingolipid biosynthesis

Pittet, Martine ; Uldry, Danièle ; Aebi, Markus ; Conzelmann, Andreas

In: Glycobiology, 2006, vol. 16, no. 2, p. 155-164

The N-glycosylation defect of cwh8Δ yeast cells causes a distinct defect in sphingolipid biosynthesis

Pittet, Martine ; Uldry, Danièle ; Aebi, Markus ; Conzelmann, Andreas

In: Glycobiology, 2006, vol. 16, no. 2, p. 155-164

CWH8/YGR036c of Saccharomyces cerevisiae has been identified as a dolichylpyrophosphate (Dol-PP) phosphatase that removes a phosphate from the Dol-PP generated by the oligosaccharyltransferase (OST), while it adds N-glycans to nascent glycoproteins in the endoplasmic reticulum (ER). Lack of CWH8 was proposed to interrupt the so called dolichol (Dol) cycle by trapping...