Université de Fribourg

Replication of segment-specific and intercalated cells in the mouse renal collecting system

Wehrli, Philipp ; Loffing-Cueni, Dominique ; Kaissling, Brigitte ; Loffing, Johannes

In: Histochemistry and Cell Biology, 2007, vol. 127, no. 4, p. 389-398

The renal collecting system (CS) is composed of segment-specific (SS) and intercalated (IC) cells. The latter comprise at least two subtypes (type A and non-type A IC). The origin and maintenance of cellular heterogeneity in the CS is unclear. Among other hypotheses, it was proposed that one subtype of IC cells represents a stem cell population from which all cell types in the CS may arise....