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Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans

Takács-Vellai, Krisztina ; Vellai, Tibor ; Chen, Estella B. ; Zhang, Yue ; Guerry, Frédéric ; Stern, Michael J. ; Müller, Fritz

In: Developmental Biology, 2007, vol. 302, no. 2, p. 661–669

The Notch signaling pathway controls growth, differentiation and patterning in divergent animal phyla; in humans, defective Notch signaling has been implicated in cancer, stroke and neurodegenerative disorders. Despite its developmental and medical significance, little is known about the factors that render cells to become competent for Notch signaling. Here we show that during vulval development...