Université de Fribourg

Antitubercular evaluation of root extract and isolated phytochemicals from Lophira lanceolata against two resistant strains of Mycobacterium tuberculosis

Nkot, Jeanne Louise ; Bikobo, Dominique Serge Ngono ; Zintchem, Auguste Abouem A ; Nyemeck II, Norbert Mbabi ; Moni Ndedi, Esther Del Florence ; Diboué, Patrick Hervé Betote ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Pharmaceutical Biology, 2018, vol. 56, no. 1, p. 318–324

Context: The roots of Lophira lanceolata Van Tiegh. Ex Keay (Ochnaceae) have numerous medicinal values in the Central African region. Even though the MeOH extract of the roots has shown antimycobacterial activities, the constituents responsible for this inhibitory activity remain unknown.Objective: Phytochemical investigation of the MeOH root extract of L. lanceolata and determination of the ...

Université de Fribourg

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

II, Norbert Mbabi Nyemeck ; Bikobo, Dominique Serge Ngono ; Zintchem, Auguste Abouem A ; Schäfer, Eva-Maria ; Bochet, Christian ; Pegnyemb, Dieudonné Emmanuel ; Koert, Ulrich

In: Natural Product Research, 2017, vol. 31, no. 24, p. 2875–2884

Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate...