Université de Neuchâtel

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Pitto-Barry, Anaïs ; Zava, Olivier ; Dyson, Paul J ; Deschenaux, Robert ; Therrien, Bruno

In: Inorganic Chemistry, 2012, vol. 51, no. 13, p. 7119-7124

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrGn) or alcohol (pyrGn-OH) (n = 1–3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metallacages, [Ru6(p-cymene) 6 (OO∩OO)3(tpt)2]6+ (OO∩OO =...

Université de Neuchâtel

Thiolato-Bridged Arene–Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2 (SR)2Cl2]

Ibao, Anne-Flore ; Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Zava, Olivier ; Dyson, Paul J.

In: European Journal of Inorganic Chemistry, 2012, vol. 2012, no. 9, p. 1531-1535

Treatment of an arene–ruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene) 2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and characterized for arene =...

Université de Neuchâtel

Thiophenolato-bridged dinuclear arene ruthenium complexes: a new family of highly cytotoxic anticancer agents

Gras, Michaël ; Therrien, Bruno ; Süss-Fink, Georg ; Zava, Olivier ; Dyson, Paul J.

In: Dalton Transactions, 2010, vol. 39, p. 10305-10313

New cationic diruthenium complexes of the type [(arene)2Ru2(SPh)3]+ , arene being C6H6, p-iPrC6H4Me, C6Me6, C6H5R, where R = (CH2)nOC(O)C6H4-p-O(CH2)6CH3 or...

Université de Neuchâtel

Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems

Barry, Nicolas P.E. ; Zava, Olivier ; Dyson, Paul J. ; Therrien, Bruno

In: Chemistry - A European Journal, 2011, vol. 17, no. 35, p. 9669-9677

A series of large cationic hexanuclear metalla-prisms, [Ru6(p-iPrC6H4Me)6(tpt)2(donq)3]6+, [Ru6(p-iPrC6H4Me)6(tpt)2(doaq)3]6+ and...

Université de Neuchâtel

Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage

Mattsson, Johan ; Zava, Olivier ; Renfrew, Anna K. ; Sei , Yoshihisa ; Yamaguchi, Kentaro ; Dyson, Paul J. ; Therrien, Bruno

In: Dalton Transactions, 2010, vol. 39, no. 35, p. 8248-8255

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene (p-PriC6H4Me) ruthenium building blocks and 2,5-dioxydo-1,4-benzoquinonato (dobq) bridges, in the presence of a functionalised pyrenyl derivative (pyrene–R), affords the triangular prismatic host–guest compounds [(pyrene–R) ⊂...

Université de Neuchâtel

Synthesis, Characterization and Anticancer Activity of Porphyrin-Containing Organometallic Cubes

Barry, Nicolas P. E. ; Zava, Olivier ; Dyson, Paul J. ; Therrien, Bruno

In: Australian Journal of Chemistry, 2010, vol. 63, no. 11, p. 1529-1537

Self-assembly of 5,10,15,20-tetra(4-pyridyl)porphyrin (tpp-H2) and 5,10,15,20-tetra(4-pyridyl)porphyrin-M(ii) (M = Ni (tpp-Ni); Zn (tpp-Zn)) tetradentate panels with the dinuclear p-cymene ruthenium clips [Ru2(p-cymene)2(C2O4)Cl2] and...

Université de Neuchâtel

Encapsulation of Pyrene-Functionalized Poly(benzyl ether) Dendrons into a Water-Soluble Organometallic Cage

Pitto-Barry, Anaïs ; Barry, Nicolas P. E. ; Zava, Olivier ; Deschenaux, Robert ; Therrien, Bruno

In: Chemistry – An Asian Journal, 2011, vol. 6, no. 6, p. 1595-1603

Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P1 and P2) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene–ruthenium metalla-cage,...

Université de Neuchâtel

Double Targeting of Tumours with Pyrenyl-Modified Dendrimers Encapsulated in an Arene–Ruthenium Metallaprism

Pitto-Barry, Anaïs ; Barry, Nicolas P. E. ; Zava, Olivier ; Deschenaux, Robert ; Dyson, Paul J. ; Therrien, Bruno

In: Chemistry – A European Journal, 2011, vol. 17, no. 6, p. 1966-1971

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene–ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges, in the presence of pyrenyl-containing dendrimers of different generations (P0, P1 and P2), affords the triangular prismatic host–guest compounds...

Université de Neuchâtel

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

Schmitt, Frédéric ; Govindaswamy, Padavattan ; Zava, Olivier ; Süss-Fink, Georg ; Juillerat-Jeanneret, Lucienne ; Therrien, Bruno

In: Journal of Biological Inorganic Chemistry, 2009, vol. 14, no. 1, p. 101-109

Mononuclear 5-(4-pyridyl)-10,15,20-triphenylporphyrin and 5-(3-pyridyl)-10,15,20-triphenylporphyrin as well as tetranuclear 5,10,15,20-tetra(4-pyridyl)porphyrin (tetra-4-pp) and 5,10,15,20-tetra(3-pyridyl)porphyrin) (tetra-3-pp) arene ruthenium(II) derivatives (arene is C6H5Me or p-PriC6H4Me) were prepared and evaluated as potential...