Università della Svizzera italiana

Polarization of migrating monocytic cells is independent of PI 3-Kinase activity

Volpe, Silvia ; Thelen, Sylvia ; Pertel. Thomas ; Lohse, Martin J. ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 4, p. e10159

Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase...

Università della Svizzera italiana

Cxcl12 evolution – subfunctionalization of a ligand through altered interaction with the chemokine receptor

Boldajipour, Bijan ; Doitsidou, Maria ; Tarbashevich, Katsiaryna ; Laguri, Cedric ; Yu, Shuizi Rachel ; Ries, Jonas ; Dumstrei, Karin ; Thelen, Sylvia ; Dörries, Julia ; Messerschmidt, Esther-Maria ; Thelen, Marcus ; Schwille, Petra ; Brand, Michael ; Lortat-Jacob, Hugues ; Raz, Erez

In: Development, 2011, vol. 138, no. 14, p. 2909-2914

The active migration of primordial germ cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo. In several vertebrates, PGC migration is guided by Cxcl12, a member of the chemokine superfamily. Interestingly, two distinct Cxcl12 paralogs are expressed in zebrafish...

Università della Svizzera italiana

ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration

Puddinu, Viola ; Casella, Sabrina ; Radice, Egle ; Thelen, Sylvia ; Dirnhofer, Stefan ; Bertoni, Francesco ; Thelen, Marcus

In: Oncotarget, 2017, vol. 8, no. 49, p. 85068-85084

Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of the chemokine system in these processes is assumed as it is known as a critical regulator of the metastatic process in cancer. The atypical...