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Université de Fribourg

Comment les régimes amaigrissants font grossir : d’une perspective d’autorégulation de la composition corporelle = How dieting makes some fatter: From a perspective of human body composition autoregulation

Dulloo, Abdul G. ; Jacquet, Jean ; Seydoux, Josiane ; Montani, Jean-Pierre

In: Cahiers de Nutrition et de Diététique, 2013, vol. 48, no. 1, p. 15–25

Le titre d’un livre publié en 1983 ‘Dieting Makes You Fat’ – concrétise la notion que faire un régime pour contrôler son poids, et par conséquent l’effet yo-yo, prédispose l’individu à être encore plus gras. Alors que cette notion est controversée, son débat souligne le fossé qui existe dans notre compréhension des lois fondamentales de la physiologie qui gouvernent la...

Université de Fribourg

A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage

Marcelino, Helena ; Veyrat-Durebex, Christelle ; Summermatter, Serge ; Sarafian, Delphine ; Miles-Chan, Jennifer ; Arsenijevic, Denis ; Zani, Fabio ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni ; Rohner-Jeanrenaud, Françoise ; Dulloo, Abdul G.

In: Diabetes, 2013, vol. 62, no. 2, p. 362-372

Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose tissue,...

Université de Fribourg

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Becattini, Barbara ; Marone, Romina ; Zani, Fabio ; Arsenijevic, Denis ; Seydoux, Josiane ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Thorens, Bernard ; Preitner, Frédéric ; Wymann, Matthias P. ; Solinas, Giovanni

In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863

Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...

Université de Fribourg

Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA

Yepuri, Gayathri ; Marcelino, Helena ; Shahkhalili, Yasaman ; Aprikian, Olivier ; Macé, Katherine ; Seydoux, Josiane ; Miles, Jennifer L. ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: British Journal of Nutrition, 2011, vol. 105, p. 1750-1763

The present study investigates whether excessive fat accumulation and hyperinsulinaemia during catch-up growth on high-fat diets are altered by n-6 and n-3 PUFA derived from oils rich in either linoleic acid (LA), α-linolenic acid (ALA), arachidonic acid (AA) or DHA. It has been shown that, compared with food-restricted rats refed a high-fat (lard) diet low in PUFA, those refed...

Université de Fribourg

Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth

Summermatter, Serge ; Marcelino, Helena ; Arsenijevic, Denis ; Buchala, Antony J. ; Aprikian, Olivier ; Assimacopoulos-Jeannet, Françoise ; Seydoux, Josiane ; Montani, Jean-Pierre ; Solinas, Giovanni ; Dulloo, Abdul G.

In: Diabetes, 2009, vol. 58, no. 10, p. 2228-2237

OBJECTIVE: Catch-up growth, a risk factor for later type 2 diabetes, is characterized by hyperinsulinemia, accelerated body-fat recovery (catch-up fat), and enhanced glucose utilization in adipose tissue. Our objective was to characterize the determinants of enhanced glucose utilization in adipose tissue during catch-up fat. RESEARCH DESIGN AND METHODS: White adipose tissue morphometry, lipogenic...

Université de Fribourg

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase

Summermatter, Serge ; Mainieri, Davide ; Russell, A. P. ; Seydoux, Josiane ; Montani, Jean-Pierre ; Buchala, Anthony J. ; Solinas, Giovanni ; Dulloo, Abdul G.

In: Faseb Journal, 2008, vol. 22, p. 774-785

Energy conservation directed at accelerating body fat recovery (or catch-up fat) contributes to obesity relapse after slimming and to excess fat gain during catch-up growth after malnutrition. To investigate the mechanisms underlying such thrifty metabolism for catch-up fat, we tested whether during refeeding after caloric restriction rats exhibiting catch-up fat driven by suppressed...

Université de Fribourg

β-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis

Mainieri, Davide ; Montani, Jean-Pierre ; Seydoux, Josiane ; Giacobino, J. P. ; Boss, O. ; Dulloo, Abdul G.

In: International Journal of Obesity, 2007, vol. 31, no. 2, p. 378–381

Mice lacking β-adrenoceptors, which mediate the thermogenic effects of norepinephrine and epinephrine, show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to obesity. In testing whether β-adrenergic...

Université de Fribourg

The thrifty 'catch-up fat' phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome

Dulloo, Abdul G. ; Jacquet, Jean ; Seydoux, Josiane ; Montani, Jean-Pierre

In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S23–S35

The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 diabetes and cardiovascular diseases later in life. The pathophysiological mechanisms by which these growth trajectories confer increased risks for these diseases are obscure, but there is...

Université de Fribourg

A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

Mainieri, Davide ; Summermatter, Serge ; Seydoux, Josiane ; Montani, Jean-Pierre ; Rusconi, Sandro ; Russell, Aaron P. ; Boss, Olivier ; Buchala, Antony J. ; Dulloo, Abdul G.

In: The FASEB Journal, 2006, vol. 20, no. 10, p. 1751-1753

An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose-specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis....