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    Université de Fribourg

    Regulation of global CD8+ T-cell positioning by the actomyosin cytoskeleton

    Stein, Jens V. ; Ruef, Nora

    In: Immunological Reviews, 2019, vol. 289, no. 1, p. 232–249

    CD8+ T cells have evolved as one of the most motile mammalian cell types, designed to continuously scan peptide–major histocompatibility complexes class I on the surfaces of other cells. Chemoattractants and adhesion molecules direct CD8+ T‐cell homing to and migration within secondary lymphoid organs, where these cells colocalize with antigen‐presenting dendritic cells in confined...