Université de Fribourg

Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters

Gai, Zhibo ; Chu, Lei ; Hiller, Christian ; Arsenijevic, Denis ; Penno, Carlos A. ; Montani, Jean-Pierre ; Odermatt, Alex ; Kullak-Ublic, Gerd A.

In: American Journal of Physiology - Renal Physiology, 2014, vol. 306, no. 1, p. F130–F137

Although the kidney is believed to play a minor role in bile acid (BA) excretion, chronic renal failure (CRF) has been reported to be associated with increased serum bile acid levels and alterations in BA homeostasis. The mechanisms for elevated BA levels are poorly understood in both clinical and experimental studies. This study was designed to examine the effects of naturally progressing CRF of...

Université de Fribourg

Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry

Penno, Carlos A. ; Arsenijevic, Denis ; Cunha, Thierry Da ; Kullak-Ublic, Gerd A. ; Montani, Jean-Pierre ; Odermatt, Alex

In: Analytical Methods, 2013, vol. 5, p. 1155-1164

In order to study the roles of individual BAs and due to limited blood sample volumes available from experimental animals, improved methods for the simultaneous quantification of multiple BAs are needed. We developed and validated an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the quantification of 24 BAs, including 11 unconjugated, 6...