Università della Svizzera italiana

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Merulla, Jessica ; Tatiana Soldà ; Maurizio Molinari

In: Molecular biology of the cell, 2015, vol. 26, no. 8, p. 1413-1574

Only native polypeptides are released from the endoplasmic reticulum (ER) to be transported at the site of activity. Persistently misfolded proteins are retained and eventually selected for ER-associated degradation (ERAD). The paradox of a structure- based protein quality control is that functional polypeptides may be destroyed if they are architecturally unfit. This has health-threatening...