Université de Fribourg

Toolbox for in vivo imaging of host–parasite interactions at multiple scales

Niz, Mariana De ; Spadin, Florentin ; Marti, Matthias ; Stein, Jens V. ; Frenz, Martin ; Frischknecht, Friedrich

In: Trends in Parasitology, 2019, vol. 35, no. 3, p. 193–212

Animal models have for long been pivotal for parasitology research. Over the last few years, techniques such as intravital, optoacoustic and magnetic resonance imaging, optical projection tomography, and selective plane illumination microscopy developed promising potential for gaining insights into host–pathogen interactions by allowing different visualization forms in vivo and ex vivo....

Université de Fribourg

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

Mantel, Pierre-Yves ; Hjelmqvist, Daisy ; Walch, Michael ; Kharoubi-Hess, Solange ; Nilsson, Sandra ; Ravel, Deepali ; Ribeiro, Marina ; Grüring, Christof ; Ma, Siyuan ; Padmanabhan, Prasad ; Trachtenberg, Alexander ; Ankarklev, ohan ; Brancucci, Nicolas M. ; Huttenhower, Curtis ; Duraisingh, Manoj T. ; Ghiran, Ionita ; Kuo, Winston P. ; Filgueira, Luis ; Martinelli, Roberta ; Marti, Matthias

In: Nature Communications, 2016, vol. 7, p. 12727

Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory responses, parasite sequestration in tissues and vascular dysfunction. Production of pro-inflammatory cytokines and chemokines promotes endothelial...