Université de Fribourg

Visible light-activated photoCORMs

Kottelat, Emmanuel ; Fabio, Zobi

In: Inorganics, 2017, vol. 5, no. 2, p. 24

Despite its well-known toxicity, carbon monoxide (CO) is now recognized as a potential therapeutic agent. Its inherent toxicity, however, has limited clinical applications because uncontrolled inhalation of the gas leads to severe systemic derangements in higher organisms. In order to obviate life-threatening effects and administer the gas by bypassing the respiratory system, CO releasing...

Université de Fribourg

Modified biovectors for the tuneable activation of anti-platelet carbon monoxide release

Prieto, Lucas ; Rossier, Jeremie ; Derszniak, Katarzyna ; Dybas, Jakub ; Oetterli, René M. ; Kottelat, Emmanuel ; Chlopicki, Stefan ; Zelder, Felix ; Zobi, Fabio

In: Chemical Communications, 2017, vol. 53, no. 51, p. 6840–6843

This communication describes the anti-platelet effects of a new class of cis-rhenium(II)- dicarbonyl-vitamin B12 complexes (B12-ReCORMs) with tuneable CO releasing properties.

Université de Fribourg

Organometallic cobalamin anticancer derivatives for targeted prodrug delivery via transcobalamin-mediated uptake

Rossier, Jeremie ; Hauser, Daniel ; Kottelat, Emmanuel ; Rothen-Rutishauser, Barbara ; Zobi, Fabio

In: Dalton Transactions, 2017, vol. 46, no. 7, p. 2159–2164

Herein we report the synthesis of new water-soluble vitamin B12 prodrugs bearing metal complexes at the β-upper side of the cobalt center. A total of three derivatives with the general design {Co–C[triple bond, length as m-dash]C-bpy–M}, where M represents a cytotoxic metal complex, were prepared and tested for their cytotoxicity against MCF-7 breast cancer cells. The choice of the metal...

Université de Fribourg

Red-light activated photoCORMs of Mn(I) species bearing electron deficient 2,2′-azopyridines

Kottelat, Emmanuel ; Ruggi, Albert ; Zobi, Fabio

In: Dalton Transactions, 2016, vol. 45, no. 16, p. 6920–6927

The realization of CO releasing molecules triggered by light (photoCORMs) within the phototherapeutic window (λ > 600 nm) constitutes an important goal for potential therapeutic applications of the molecules. The activation of photoCORMs with red/NIR light would enable exploiting the higher depth of penetration of this radiation with respect to higher energy photons. In this article we...

Université de Fribourg

Towards cardiolite-inspired carbon monoxide releasing molecules – Reactivity of d4, d5 rhenium and d6 manganese carb­onyl complexes with isocyanide ligands

Kottelat, Emmanuel ; Chabert, Valentin ; Crochet, Aurélien ; Fromm, Katharina M. ; Zobi, Fabio

In: European Journal of Inorganic Chemistry, 2015, vol. 2015, no. 34, p. 5628–5638

Carbon monoxide releasing molecules (CORMs) are investigated widely in synthetic and medicinal chemistry owing to the potential therapeutic applications of the CO gas. Organometallic carbonyl complexes are best suited to play the role of CO carriers as they allow the exogenous release of CO under controlled conditions, and the toxicity of the gas can be overcome. With the long-term goal of...

Université de Fribourg

Polymorph of dibenzo-24-crown-8 and its mercury complex

Crochet, Aurélien ; Kottelat, Emmanuel ; Fleury, Antoine ; Neuburger, Markus ; Fromm, Katharina M.

In: Zeitschrift für anorganische und allgemeine Chemie, 2011, vol. 637, no. 6, p. 672–675

Dibenzo-24-crown-8 is studied herein as a flexible ligand able to adopt different conformations, as well as for the complexation of mercury. The recrystallization of dibenzo-24-crown-8 (DB24C8) from dry THF gives a new polymorphic structure of this ligand. This new structure is described and compared to the literature compound. Additionally, coordination of this ligand to mercury iodide HgI₂ is...