Université de Fribourg

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert ; Ngono Bikobo, Dominique Serge ; Zintchem, Auguste Abouem A. ; Mbabi Nyemeck II, Norbert ; Moni Ndedi, Esther Del Florence ; Betote Diboué, Patrick Hervé ; Nyegue, Maximilienne Ascension ; Atchadé, Alex de Théodore ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Natural Product Research, 2019, vol. 33, no. 5, p. 642–650

Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol...

Université de Fribourg

Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae)

Messanga, Robert Ebeh ; Ngono Bikobo, Dominique Serge ; Zintchem, Auguste Abouem A. ; Mbabi Nyemeck, II Norbert ; Moni Ndedi, Esther Del Florence ; Betote Diboué, Patrick Hervé ; Nyegue, Maximilienne Ascension ; Atchadé, Alex De Théodore ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Natural Product Research, 2018, vol. 32, no. 16, p. 1971–1976

The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine (6) and...

Université de Fribourg

Antitubercular evaluation of root extract and isolated phytochemicals from Lophira lanceolata against two resistant strains of Mycobacterium tuberculosis

Nkot, Jeanne Louise ; Bikobo, Dominique Serge Ngono ; Zintchem, Auguste Abouem A ; Nyemeck II, Norbert Mbabi ; Moni Ndedi, Esther Del Florence ; Diboué, Patrick Hervé Betote ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Pharmaceutical Biology, 2018, vol. 56, no. 1, p. 318–324

Context: The roots of Lophira lanceolata Van Tiegh. Ex Keay (Ochnaceae) have numerous medicinal values in the Central African region. Even though the MeOH extract of the roots has shown antimycobacterial activities, the constituents responsible for this inhibitory activity remain unknown.Objective: Phytochemical investigation of the MeOH root extract of L. lanceolata and determination of the ...

Université de Fribourg

In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

Evina, Jean Noel ; Bikobo, Dominique Serge Ngono ; Zintchem, ?, Auguste Abouem A. ; Nyemeck II, Norbert Mbabi ; Ndedi, Esther Del Florence Moni ; Diboué, Patrick Hervé Betote ; Nyegue, Maximilienne Ascension ; Atchadé, Alex de Théodore ; Pegnyemb, Dieudonné Emmanuel ; Koert, Ulrich ; Bochet, Christian G.

In: Revista Brasileira de Farmacognosia, 2017, vol. 27, no. 6, p. 739–743

A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β- glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-d-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6″- O-acetylvitexin, quercetin 3-O-β-d-glucopyranoside. The structures...

Université de Fribourg

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

II, Norbert Mbabi Nyemeck ; Bikobo, Dominique Serge Ngono ; Zintchem, Auguste Abouem A ; Schäfer, Eva-Maria ; Bochet, Christian ; Pegnyemb, Dieudonné Emmanuel ; Koert, Ulrich

In: Natural Product Research, 2017, vol. 31, no. 24, p. 2875–2884

Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate...