Université de Fribourg

Dynamics of actinotrichia regeneration in the adult zebrafish fin

König, Désirée ; Page, Lionel ; Chassot, Bérénice ; Jaźwińska, Anna

In: Developmental Biology, 2018, vol. 433, no. 2, p. 416–432

The skeleton of adult zebrafish fins comprises lepidotrichia, which are dermal bones of the rays, and actinotrichia, which are non-mineralized spicules at the distal margin of the appendage. Little is known about the regenerative dynamics of the actinotrichia- specific structural proteins called Actinodins. Here, we used immunofluorescence analysis to determine the contribution of two...

Université de Fribourg

Bone morphogenetic protein signaling promotes morphogenesis of blood vessels, wound epidermis, and actinotrichia during fin regeneration in zebrafish

Thorimbert, Valentine ; König, Désirée ; Marro, Jan ; Ruggiero, Florence ; Jaźwińska, Anna

In: The FASEB Journal, 2015, p. fj.15–272955

Zebrafish fin regeneration involves initial formation of the wound epidermis and the blastema, followed by tissue morphogenesis. The mechanisms coordinating differentiation of distinct tissues of the regenerate are poorly understood. Here, we applied pharmacologic and transgenic approaches to address the role of bone morphogenetic protein (BMP) signaling during fin restoration. To map the BMP...