Université de Fribourg

HDAC1 and HDAC2 Control the specification of neural crest cells into peripheral glia

Jacob, Claire ; Lötscher, Pirmin ; Engler, Stefanie ; Baggiolini, Arianna ; Tavares, Sandra Varum ; Brügger, Valérie ; John, Nessy ; Büchmann-Møller, Stine ; Snider, Paige L. ; Conway, Simon J. ; Yamaguchi, Teppei ; Matthias, Patrick ; Sommer, Lukas ; Mantei, Ned ; Suter, Ueli

In: The Journal of Neuroscience, 2014, vol. 34, no. 17, p. 6112–6122

Schwann cells, the myelinating glia of the peripheral nervous system (PNS), originate from multipotent neural crest cells that also give rise to other cells, including neurons, melanocytes, chondrocytes, and smooth muscle cells. The transcription factor Sox10 is required for peripheral glia specification. However, all neural crest cells express Sox10 and the mechanisms directing neural crest...