Université de Neuchâtel

Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex

Giannini, Federico ; Furrer, Julien ; Süss-Fink, Georg

In: Inorganic Chemistry, 2011, vol. 50, no. 21, p. 10552–10554

The highly cytotoxic diruthenium complex [(p-MeC6H4Pri)2Ru2(SC6H4-p-Me)3]+ (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro...