Université de Fribourg

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

Secondini, Chiara ; Coquoz, Oriana ; Spagnuolo, Lorenzo ; Spinetti, Thibaud ; Peyvandi, Sanam ; Ciarloni, Laura ; Botta, Francesca ; Bourquin, Carole ; Rüegg, Curzio

In: OncoImmunology, 2017, vol. 6, no. 6, p. e1316437

Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumulation of myeloid-derived suppressor cells (MDSC) during tumor progression and therapy have been implicated in metastasis formation and resistance to...

Université de Fribourg

Development and clinical validation of a blood test based on 29-gene expression for early detection of colorectal cancer

Ciarloni, Laura ; Ehrensberger, Sahar Hosseinian ; Imaizumi, Natsuko ; Monnier-Benoit, Sylvain ; Nichita, Cristina ; Myung, Seung-Jae ; Kim, Joo Sung ; Song, Si Young ; Kim, Tae Il ; Weg, Boudewijn van der ; Meier, Rémy ; Borovicka, Jan ; Beglinger, Christoph ; Vallet, Cédric ; Maerten, Philippe ; Rüegg, Curzio ; Dorta, Gian

In: Clinical Cancer Research, 2016, p. -

A blood test for colorectal cancer (CRC) screening is a valuable tool to for testing asymptomatic individuals and reducing CRC-related mortality. The objective of this study was to develop and validate a novel blood test able to differentiate patients with CRC and adenomatous polyps (AP) from individuals with a negative colonoscopy. Experimental Design: A case-control, multicenter clinical...

Université de Fribourg

Discovery of a 29-gene panel in peripheral blood mononuclear cells for the detection of colorectal cancer and adenomas using high throughput real-time PCR

Ciarloni, Laura ; Hosseinian, Sahar ; Monnier-Benoit, Sylvain ; Imaizumi, Natsuko ; Dorta, Gian ; Ruegg, Curzio

In: PLoS ONE, 2015, vol. 10, no. 4, p. e0123904

Colorectal cancer (CRC) is the second leading cause of cancer-related death in developed countries. Early detection of CRC leads to decreased CRC mortality. A blood-based CRC screening test is highly desirable due to limited invasiveness and high acceptance rate among patients compared to currently used fecal occult blood testing and colonoscopy. Here we describe the discovery and validation of a...

Université de Fribourg

Proangiogenic factor PlGF programs CD11b+ myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors

Laurent, Julien ; Faes-van't Hull, Eveline ; Touvrey, Cedric ; Kuonen, Francois ; Lan, Qiang ; Lorusso, Girieca ; Doucey, Marie-Agnes ; Ciarloni, Laura ; Imaizumi, Natsuko ; Alghisi, Gian Carlo ; Fagiani, Ernesta ; Zaman, Khalil ; Stupp, Roger ; Shibuya, Masabumi ; Delaloye, Jean-François ; Christofori, Gerhard ; Ruegg, Curzio

In: Cancer Research, 2011, p. -

Tumor-mobilized bone marrow-derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here we show that CD11b+ myelomonocytic cells develop proangiogenic properties during their differentiation from CD34+ hematopoietic progenitors and that Placenta Growth Factor (PlGF) is critical in promoting this education....