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Consortium of Swiss Academic Libraries

EMT, the cytoskeleton, and cancer cell invasion

Yilmaz, Mahmut ; Christofori, Gerhard

In: Cancer and Metastasis Reviews, 2009, vol. 28, no. 1-2, p. 15-33

Université de Fribourg

The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression

Huang, Yu-Ting ; Lan, Qiang ; Ponsonnet, Lionel ; Blanquet, Marisa ; Christofori, Gerhard ; Zaric, Jelena ; Rüegg, Curzio

In: Oncotarget, 2015, vol. 7, no. 2, p. 1663–1674

The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In this study, we investigated the role of the matricellular protein Cysteine-rich 61 (CYR61) in pancreatic islet development and carcinogenesis....

Université de Fribourg

An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models

Fagiani, Ernesta ; Bill, Ruben ; Pisarsky, Laura ; Ivanek, Robert ; Rüegg, Curzio ; Christofori, Gerhard

In: Angiogenesis, 2015, vol. 18, no. 3, p. 327–345

Tumor growth depends on the formation of new blood vessels (tumor angiogenesis) either from preexisting vessels or by the recruitment of bone marrow-derived cells. Despite encouraging results obtained with preclinical cancer models, the therapeutic targeting of tumor angiogenesis has thus far failed to deliver an enduring clinical response in cancer patients. One major obstacle for improving...

Université de Fribourg

Concepts of metastasis in flux: the stromal progression model

Sleeman, Jonathan P. ; Christofori, Gerhard ; Fodde, Riccardo ; Collard, John G. ; Berx, Geert ; Decraene, Charles ; Rüegg, Curzio

In: Seminars in Cancer Biology, 2012, p. -

The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic...

Université de Fribourg

Proangiogenic factor PlGF programs CD11b+ myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors

Laurent, Julien ; Faes-van't Hull, Eveline ; Touvrey, Cedric ; Kuonen, Francois ; Lan, Qiang ; Lorusso, Girieca ; Doucey, Marie-Agnes ; Ciarloni, Laura ; Imaizumi, Natsuko ; Alghisi, Gian Carlo ; Fagiani, Ernesta ; Zaman, Khalil ; Stupp, Roger ; Shibuya, Masabumi ; Delaloye, Jean-François ; Christofori, Gerhard ; Ruegg, Curzio

In: Cancer Research, 2011, p. -

Tumor-mobilized bone marrow-derived CD11b+ myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here we show that CD11b+ myelomonocytic cells develop proangiogenic properties during their differentiation from CD34+ hematopoietic progenitors and that Placenta Growth Factor (PlGF) is critical in promoting this education....