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Université de Fribourg

Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice

Bahi, Amine ; Dreyer, Jean-Luc

In: Behavioural Brain Research, 2019, vol. 359, p. 104–115

Many epidemiological and clinical studies have demonstrated a strong comorbidity between anxiety and depression, and a number of experimental studies indicates that the dopamine transporter (DAT) is involved in the pathophysiology of anxiety and depression. However, studies using laboratory animals have yielded inconclusive results. The aim of the present study was to examine the effects of...

Université de Fribourg

Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2018, vol. 28, no. 12, p. 1394–1404

Generalized anxiety and major depression disorders (MDD) are severe debilitating mood disorders whose etiology are not fully understood, but growing evidence indicates that microRNAs (miRNAs) might play a key role in their neuropathophysiological mechanisms. In the current study, we investigate the role of Lethal-7 (let-7d) miRNA, and its direct target dopamine D3 receptor (D3R) gain-of-...

Université de Fribourg

Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats

Bahi, Amine ; Dreyer, Jean-Luc

In: Psychopharmacology, 2017, p. 1–12

Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays a fundamental role in the nervous system. Recent research has suggested that this transcription factor is associated with the pathophysiology of psychiatric disorders including addiction, schizophrenia, and depression. However, the role of MyT1 in anxiety- and ethanol-related behaviors is still...

Université de Fribourg

Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

Pisanu, Augusta ; Lecca, Daniele ; Valentini, Valentina ; Bahi, Amine ; Dreyer, Jean-Luc ; Cacciapaglia, Fabio ; Scifo, Andrea ; Piras, Giovanna ; Cadoni, Cristina ; Chiara, Gaetano Di

In: Neuropharmacology, 2015, vol. 89, p. 398–411

Microdialysis during i.v. drug self-administration (SA) have implicated nucleus accumbens (NAc) shell DA in cocaine and heroin reinforcement. However, this correlative evidence has not been yet substantiated by experimental evidence obtained by studying the effect of selective manipulation of NAc shell DA transmission on cocaine and heroin SA. In order to investigate this issue, DA D1a receptor...

Université de Fribourg

Lentiviral vector-mediated dopamine D3 receptor modulation in the rat brain impairs alcohol intake and ethanol-induced conditioned place preference

Bahi, Amine ; Dreyer, Jean-Luc

In: Alcoholism: Clinical and Experimental Research, 2014, vol. 38, no. 9, p. 2369–2376

Background: It has been reported that dopamine D3 receptor (D3R) knockout mice display similar ethanol (EtOH) consumption compared to wild types. In addition, studies with D3R pharmacological targeting were inconclusive.Methods: In the current study, we used both gain- and loss-of-function approaches to test the effects of central D3R manipulation on voluntary alcohol intake and EtOH-induced...

Université de Fribourg

BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions

Vargas-Perez, Hector ; Bahi, Amine ; Bufalino, Mary Rose ; Ting-A-Kee, Ryan ; Maal-Bared, Geith ; Lam, Jenny ; Fahmy, Ahmed ; Clarke, Laura ; Blanchard, Jennifer K. ; Larsen, Brett R. ; Steffensen, Scott ; Dreyer, Jean-Luc ; Kooy, Derek van der

In: The Journal of Neuroscience, 2014, vol. 34, no. 23, p. 7899–7909

Drug administration to avoid unpleasant drug withdrawal symptoms has been hypothesized to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural relationship between the aversive motivational state produced by drug withdrawal and the development of the drug-dependent state still remains elusive. It has been observed that chronic exposure to drugs of abuse increases...

Université de Fribourg

Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats

Bahi, Amine ; Chandrasekar, Vijay ; Dreyer, Jean-Luc

In: Psychoneuroendocrinology, 2014, vol. 46, p. 78–87

Several lines of evidences suggest that the brain-derived neutrophic factor (BDNF) is implicated in the pathophysiology of depression. However, the molecular mechanisms are not fully understood. In the current study we aimed to investigate how genetic modulation of BDNF in the hippocampus using microRNa124a (miR124a)-expressing lentiviral vectors (LV) might affect depression-like behavior in...